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Online detection and sorting of extracellularly recorded action potentials in human medial temporal lobe recordings, in vivo
TLDR
This method will allow the development of "closed-loop" experiments, which immediately adapt the experimental stimuli and/or tasks to the neural response observed, and is demonstrated by applying it to an extensive data set acquired from chronically implanted depth electrodes in the hippocampus of human epilepsy patients. Expand
Conductivities of Three-Layer Live Human Skull
TLDR
The conductivities of the skull layers are frequency dependent in the 10-90 Hz region and are non-ohmic in the 0.45-2.07 A/m2 region, which are much higher than those occurring in human brain. Expand
Human memory strength is predicted by theta-frequency phase-locking of single neurons
TLDR
It is shown that successful memory formation in humans is predicted by a tight coordination of spike timing with the local theta oscillation, providing a link between the known modulation of theTA oscillations by many memory-modulating behaviours and circuit mechanisms of plasticity. Expand
Nocardial Brain Abscess: Treatment Strategies and Factors Influencing Outcome
TLDR
The authors recommend image-directed stereotactic aspiration for diagnosis and craniotomy and total excision are necessary in most cases, because nocardial abscesses are usually multiloculated. Expand
Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task
TLDR
It is found that when humans are required to use spatial cues to navigate to a hidden escape platform in a pool, patients with HPC resections display severe impairments in spatial navigation relative to age-matched controls and age- matched patients who have had extra-HPC resection. Expand
Single-Trial Learning of Novel Stimuli by Individual Neurons of the Human Hippocampus-Amygdala Complex
TLDR
Two classes of neurons in the hippocampus and amygdala that exhibit single-trial learning are reported: novelty and familiarity detectors, which show a selective increase in firing for new and old stimuli, respectively. Expand
EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas.
TLDR
Results indicate that inhibiting EGFR signaling may be a novel strategy for treating Cushing disease and preferentially targeted EGFR to mouse corticotroph cell nuclei, which resulted in higher Pomc expression and ACTH secretion, both of which were inhibited by gefitinib. Expand
Nocardial brain abscess: treatment strategies and factors influencing outcome.
TLDR
The authors recommend image-directed stereotactic aspiration for diagnosis and craniotomy and total excision are necessary in most cases, because nocardial abscesses are usually multiloculated. Expand
Improved Management of Multiple Brain Abscesses: A Combined Surgical and Medical Approach: 76
TLDR
A combined surgical and medical approach should yield cure rates of more than 90% in patients with multiple brain abscesses, a result similar to that expected when treating patients with solitary lesions. Expand
Treatment options and prognosis for multicentric juvenile pilocytic astrocytoma.
TLDR
It is concluded that multicentric spread of JPA occurs more frequently than was previously recognized and in patients with subtotally resected JPA and several years of follow-up review via magnetic resonance imaging, the incidence of recurrence in a site different from the original was 12%. Expand
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