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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Expand
Genome-wide association study identifies five new schizophrenia loci
The role of common genetic variation in schizophrenia in a genome-wide association study of substantial size is examined, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. Expand
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method.
  • A. Breier, T. Su, +8 authors D. Pickar
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 18 March 1997
In the clinical study, patients with schizophrenia compared with healthy volunteers had significantly greater amphetamine-related reductions in [11C]raclopride specific binding, providing direct evidence for the hypothesis of elevated Amphetamine-induced synaptic dopamine concentrations in schizophrenia. Expand
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance ineducational attainment and 7–10% ofthe variance in cognitive performance, which substantially increases the utility ofpolygenic scores as tools in research. Expand
Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents.
Weight gain and changes in lipid and metabolic parameters in patients without prior antipsychotic medication exposure are studied and mean levels increased significantly for total cholesterol, triglycerides, and non-high-density lipoprotein cholesterol. Expand
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. Expand
NMDA Receptor Function and Human Cognition: The Effects of Ketamine in Healthy Volunteers
The effects of subanesthetic doses of ketamine on two forms of memory, free recall and recognition, as well as attention and behavior in 15 healthy volunteers are examined, suggesting that the NMDA receptor plays a direct role in two types of explicit memory. Expand
Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia
It was found that runs of homozygosity (ROHs), ranging in size from 200 kb to 15 mb, were common in unrelated Caucasians, and several of these risk ROHs were very rare in healthy subjects, suggesting that recessive effects of relatively high penetrance may explain a proportion of the genetic liability for SCZ. Expand
A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.
These data are consistent with those of previous studies, suggesting that a functional genetic polymorphism may influence prefrontal cognition. Expand
Neurocognitive correlates of the COMT Val158Met polymorphism in chronic schizophrenia
The findings provide independent support for the hypothesis that the catechol-O-methyltransferase Val(158)Met polymorphism influences neurocognitive function in schizophrenia, and suggest that the functional effects may be expressed on measures of Processing Speed and Attention. Expand