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Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults.
BACKGROUND Obstructive sleep apnea (OSA) is a common chronic disorder that often requires lifelong care. Available practice parameters provide evidence-based recommendations for addressing aspects ofExpand
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Mechanical ventilation guided by esophageal pressure in acute lung injury.
BACKGROUND Survival of patients with acute lung injury or the acute respiratory distress syndrome (ARDS) has been improved by ventilation with small tidal volumes and the use of positiveExpand
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Adult obstructive sleep apnoea
Obstructive sleep apnoea is an increasingly common disorder of repeated upper airway collapse during sleep, leading to oxygen desaturation and disrupted sleep. Features include snoring, witnessedExpand
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Obstructive sleep apnoea
Obstructive sleep apnoea is a disease of increasing importance because of its neurocognitive and cardiovascular sequelae. Abnormalities in the anatomy of the pharynx, the physiology of the upperExpand
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Association between reduced sleep and weight gain in women.
Physiologic studies suggest that sleep restriction has metabolic effects that predispose to weight gain. The authors investigated the association between self-reported usual sleep duration andExpand
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A prospective study of sleep duration and coronary heart disease in women.
BACKGROUND Long-term sleep deprivation is common in today's society. Recent experiments have demonstrated that short-term sleep deprivation in healthy subjects results in adverse physiologic changes,Expand
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Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data
Background: Hyperglycemia is associated with increased mortality in critically ill patients. Randomized trials of intensive insulin therapy have reported inconsistent effects on mortality andExpand
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Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets.
RATIONALE The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among patients but have not been well characterized. OBJECTIVES To define carefully the proportion of key anatomicExpand
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Central sleep apnea: Pathophysiology and treatment.
Central sleep apnea (CSA) is characterized by a lack of drive to breathe during sleep, resulting in repetitive periods of insufficient ventilation and compromised gas exchange. These nighttimeExpand
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Pathophysiology of adult obstructive sleep apnea.
Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive narrowing or collapse of the pharyngeal airway during sleep. The disorder is associated with major comorbiditiesExpand
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