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Nonribosomal Peptide Synthesis-Principles and Prospects.
Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that assemble numerous peptides with large structural and functional diversity. These peptides include more than 20 marketedExpand
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The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client
Small heat-shock proteins, including αB-crystallin (αB), play an important part in protein homeostasis, because their ATP-independent chaperone activity inhibits uncontrolled protein aggregation.Expand
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Structural and Mechanistic Implications of Metal Binding in the Small Heat-shock Protein αB-crystallin*
Background: αB-crystallin is an ATP-independent chaperone that prevents irreversible protein aggregation. Results: Cu(II) binds to the core domain of αB-crystallin, induces increased dynamics at theExpand
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Paenilamicin: structure and biosynthesis of a hybrid nonribosomal peptide/polyketide antibiotic from the bee pathogen Paenibacillus larvae.
The spore-forming bacterium Paenibacillus larvae is the causative agent of American Foulbrood (AFB), a fatal disease of honey bees that occurs worldwide. Previously, we identified a complex hybridExpand
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Biochemical Dissection of the Natural Diversification of Microcystin Provides Lessons for Synthetic Biology of NRPS.
The cyanobacterial hepatotoxin microcystin is assembled at a non-ribosomal peptide synthetase (NRPS) complex. The enormous structural diversity of this peptide, which is also found in closely relatedExpand
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The mechanism of denaturation and the unfolded state of the α-helical membrane-associated protein Mistic.
In vitro protein-folding studies using chemical denaturants such as urea are indispensible in elucidating the forces and mechanisms determining the stability, structure, and dynamics of water-solubleExpand
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Large protein complexes with extreme rotational correlation times investigated in solution by magic-angle-spinning NMR spectroscopy.
We show that large protein complexes can be investigated in solution using magic-angle-spinning (MAS) NMR spectroscopy without the need for sample crystallization or precipitation. In order toExpand
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The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine.
Albicidin is a potent DNA gyrase inhibitor produced by the sugarcane pathogenic bacterium Xanthomonas albilineans. Here we report the elucidation of the hitherto unknown structure of albicidin,Expand
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Dynamics in the solid-state: perspectives for the investigation of amyloid aggregates, membrane proteins and soluble protein complexes
Aggregates formed by amyloidogenic peptides and proteins and reconstituted membrane protein preparations differ significantly in terms of the spectral quality that they display in solid-state NMRExpand
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