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The Community Earth System Model (CESM) large ensemble project: a community resource for studying climate change in the presence of internal climate variability
AbstractWhile internal climate variability is known to affect climate projections, its influence is often underappreciated and confused with model error. Why? In general, modeling centers contributeExpand
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TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration.
How regeneration cues are converted into the epigenetic information that controls gene expression in adult stem cells is currently unknown. We identified an inflammation-activated signaling in muscleExpand
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BLUEPRINT to decode the epigenetic signature written in blood
volume 30 number 3 march 2012 nature biotechnology To the Editor: Last October, scientists gathered in Amsterdam to celebrate the start of BLUEPRINT (http://www.blueprintepigenome.eu/), an EU-fundedExpand
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Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue
Chromatin modifications are sensitive to environmental and nutritional stimuli. Abnormalities in epigenetic regulation are associated with metabolic disorders such as obesity and diabetes that areExpand
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Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2.
LSD1 and LSD2 histone demethylases are implicated in a number of physiological and pathological processes, ranging from tumorigenesis to herpes virus infection. A comprehensive structural,Expand
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Epi-drugs to fight cancer: from chemistry to cancer treatment, the road ahead.
  • A. Mai, L. Altucci
  • Biology, Medicine
  • The international journal of biochemistry & cell…
  • 2009
In addition to genetic events, a variety of epigenetic events have been widely reported to contribute to the onset of many diseases including cancer. DNA methylation and histone modifications (suchExpand
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HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment
The overlapping histological and biochemical features underlying the beneficial effect of deacetylase inhibitors and NO donors in dystrophic muscles suggest an unanticipated molecular link amongExpand
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Histone deacetylation in epigenetics: An attractive target for anticancer therapy
The reversible histone acetylation and deacetylation are epigenetic phenomena that play critical roles in the modulation of chromatin topology and the regulation of gene expression. AberrantExpand
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Oxidative Stress and Epigenetic Regulation in Ageing and Age-Related Diseases
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, whereExpand
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p300/CBP-Associated Factor Selectively Regulates the Extinction of Conditioned Fear
It is well established that the activity of chromatin-modifying enzymes is crucial for regulating gene expression associated with hippocampal-dependent memories. However, very little is known aboutExpand
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