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FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver.
Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome.
The data highlights the usefulness of a polygenetic animal model for screening of compounds affecting food intake, body weight, and glucose homeostasis and underscores the effectiveness of GLP-1 mimetics both as anti-diabetes and anti-obesity agents.
PYY(3-36) reduces food intake and body weight and improves insulin sensitivity in rodent models of diet-induced obesity.
- N. Vrang, A. Madsen, M. Tang-Christensen, G. Hansen, P. J. Larsen
- Biology, MedicineAmerican journal of physiology. Regulatory…
- 13 April 2006
A single intraperitoneal injection of PYY(3-36) inhibited food intake in mice, but not in rats, and increasing doses reduced body weight and improved glycemic control in glucose-intolerant DIO rats.
GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines.
GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40).
The 2-monoacylglycerol receptor GPR119 is at least as important as the long-chain fatty acid receptor FFA1 in mediating the TG-induced secretion of incretins and that the 2 receptors act in synergy, whereas FFA4 plays a minor if any role.
In vivo characterization of high Basal signaling from the ghrelin receptor.
The receptor for the orexigenic peptide, ghrelin, is one of the most constitutively active 7TM receptors known, as demonstrated under in vitro conditions and the expression in the hypothalamus was up-regulated approximately 2-fold in rats both during 48-h fasting and by streptozotocin-induced hyperphagia.
Dietary fat decreases intestinal levels of the anorectic lipids through a fat sensor
The intestinal NAE levels are reduced in a dose‐ and time‐dependent manner in response to dietary fat intake, and this may contribute to the well‐known hyperphagic effect of HFDs.
Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism.
The 2 gut hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are well known to be coexpressed, costored, and released together to coact in the control of key metabolic target organs.…
PICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose Tolerance
Two lipid membrane sculpting BAR domain proteins, PICK1 and ICA69, play a key role early in the biogenesis of peptide hormone secretory vesicles and are critical for normal growth and metabolic…