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A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans
Cumulatively, the results suggest that CAR-1 functions with CGH-1 to regulate a specific set of maternally loaded RNAs that is required for anaphase spindle structure and cytokinesis. Expand
RhoA is required for cortical retraction and rigidity during mitotic cell rounding
It is suggested that the mitotic increase in RhoA activity leads to rearrangements of the cortical actin cytoskeleton that promote cortical rigidity, resulting in mitotic cell rounding. Expand
Anillin and the septins promote asymmetric ingression of the cytokinetic furrow.
Asymmetric furrow ingression, a prevalent but previously unexplored feature of cell division in metazoans, is generated by the action of two conserved furrow components and serves a mechanical function that makes cytokinesis robust. Expand
Simultaneous stretching and contraction of stress fibers in vivo.
It is observed that stress fibers, unlike muscle myofibrils, do not contract uniformly along their lengths, and higher levels of MLC and phosphorylated MLC are detected in the peripheral region of stress fibers. Expand
Distinct roles for two C. elegans anillins in the gonad and early embryo
It is shown that ANI-1 and ANi-2 contribute to embryonic viability by performing distinct functions in the early embryo and gonad, respectively, and thatANI-3 appears to be dispensable for embryonic development. Expand
A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A
High-resolution live-cell imaging assays demonstrated that MgcRacGAP, the Rho family guanine nucleotide exchange factor (GEF) Ect2, and the small GTPases Cdc42 and Rac, are required for stability of newly incorporated CENP-A at centromeres, ensuring epigenetic centromere maintenance after loading of new CENp-A. Expand
The myriad roles of Anillin during cytokinesis.
  • A. Piekny, A. Maddox
  • Biology, Medicine
  • Seminars in cell & developmental biology
  • 1 December 2010
Study of Anillin in several model organisms has provided insight into how the cytoskeleton is coordinated to ensure that cytokinesis occurs with high fidelity, and questions of how these interactions are coordinated are discussed. Expand
Cytokinesis, ploidy and aneuploidy
In this review, several examples of normal and pathological polyploidy are highlighted, focusing on those caused by a controlled failure or dysregulation of cytokinesis, respectively and therapeutic routes to control cytokineis to restore or block cell division are proposed. Expand
The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly
It is shown that simultaneous inhibition of the CPC kinase Aurora B(AIR-2) and the centralspindlin component MKLP1(ZEN-4) causes an additive constriction defect, which is consistent with distinct roles for the proteins. Expand
Actomyosin Tube Formation in Polar Body Cytokinesis Requires Anillin in C. elegans
It is proposed that cytoskeletal bundling by anillin promotes formation of the midbody tube, which ensures the fidelity of PBE, and analysis of mouse PBE indicates that mid body tube formation is a conserved process. Expand