• Publications
  • Influence
AKT Facilitates EGFR Trafficking and Degradation by Phosphorylating and Activating PIKfyve
Receptor tyrosine kinases limit their own activity by stimulating kinases that promote trafficking of the receptors to the lysosome. Promoting One’s Own Demise Mutations in the genes encodingExpand
  • 81
  • 11
PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation
A feedback loop involving PIP4kγ and mTORC1 maintains basal mTORC1 activity under nutrient-deprived conditions. Maintaining a Basal Level of Activity Nutrients such as glucose and amino acidsExpand
  • 21
  • 3
Stress‐induced activation of Nox contributes to cell survival signalling via production of hydrogen peroxide
Reactive oxygen species (ROS) have traditionally been viewed as a toxic group of molecules; however, recent publications have shown that these molecules, including H2O2, can also strongly promoteExpand
  • 52
  • 2
IGF‐I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death
Retinitis pigmentosa is a heterogeneous group of inherited retinal dystrophies in which the loss of photoreceptor cells via apoptosis leads to blindness. In this study we have experimentally mimickedExpand
  • 32
  • 2
A stress survival response in retinal cells mediated through inhibition of the serine / threonine phosphatase PP2A
Cell survival signalling involving the PI3K/Akt survival pathway can be negatively regulated by several phosphatases including PP2A. When retinal‐derived 661W cells were subjected to trophic factorExpand
  • 17
A Proinflammatory Function of Toll-Like Receptor 2 in the Retinal Pigment Epithelium as a Novel Target for Reducing Choroidal Neovascularization in Age-Related Macular Degeneration.
  • L. Feng, M. Ju, +8 authors Y. Ng
  • Medicine
  • The American journal of pathology
  • 1 October 2017
Current treatments for choroidal neovascularization, a major cause of blindness for patients with age-related macular degeneration, treat symptoms but not the underlying causes of the disease.Expand
  • 8
IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3
Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 isExpand
  • 6
Imaging rhodopsin degeneration in vivo in a new model of ocular ischemia in living mice
Delivery of antibodies to monitor key biomarkers of retinopathy in vivo represents a significant challenge because living cells do not take up immunoglobulins to cellular antigens. We met thisExpand
  • 3
Fibrotic Changes and Endothelial-to-Mesenchymal Transition Promoted by VEGFR2 Antagonism Alter the Therapeutic Effects of VEGFA Pathway Blockage in a Mouse Model of Choroidal Neovascularization
Many patients with wet age-related macular degeneration do not respond well to anti- vascular endothelial growth factor A (VEGFA) therapy for choroidal neovascularization (CNV), and the efficacy ofExpand
  • 1
  • PDF