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Rapid environmental changes in southern Europe during the last glacial period
Oxygen-isotope records from Greenland ice cores, indicate numerous rapid climate fluctuations during the last glacial period. North Atlantic marine sediment cores show comparable variability in sea… Expand
Alkenone and boron based Pliocene pCO2 records
Abstract The Pliocene period is the most recent time when the Earth was globally significantly (∼ 3 °C) warmer than today. However, the existing pCO2 data for the Pliocene are sparse and there is… Expand
The δ13C in benthic foraminiferal tests of Fontbotia wuellerstorfi (Schwager) Relative to the δ13C of dissolved inorganic carbon in Southern Ocean Deep Water: Implications for glacial ocean…
On a transect between 20° and 70°S in the eastern Atlantic Ocean and Weddell Sea, water samples from 19 hydrographic stations and bottom water from 55 surface sediment samples taken with a multiple… Expand
Inhibitory effect of tumor cell-derived lactic acid on human T cells.
The findings suggest that targeting this metabolic pathway in tumors is a promising strategy to enhance tumor immunogenicity and block lactic acid export in T cells, thereby disturbing their metabolism and function. Expand
Environmental and biological effects on the stable isotope composition of recent deep-sea benthic foraminifera from the western Mediterranean Sea
Abstract The influence of microhabitat, organic matter flux, and metabolism on the stable oxygen and carbon isotope composition of live (Rose Bengal stained) and dead (empty tests) deep-sea benthic… Expand
Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion
Recent clinical data support ideas of Programmed death receptor-ligand 1 (PD-L1; also called B7-H1, CD274) playing an important role in immune evasion of tumor cells. Expression of PD-L1 on tumors… Expand
Sedimentological evidence for the formation of an East Antarctic ice sheet in Eocene/Oligocene time
Middle Eocene to late Oligocene sediments recovered at Ocean Drilling Program Sites 689 and 690 on Maud Rise in the southernmost Atlantic Ocean and at Sites 738 and 744 on Kerguellen Plateau in the… Expand
Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy
The currently available data concerning negative T-cell regulation via PD-1, the blockade of PD-L1/PD-1 interactions, and the implications for adoptive T- cell therapies are discussed. Expand
Late Pleistocene deep-water circulation in the subantarctic eastern Atlantic
We present three new benthic foraminiferal δ13C, δ18O, and total organic carbon time series from the eastern Atlantic sector of the Southern Ocean between 41°S and 47°S. The measured glacial δ13C… Expand
Tumor-derived lactic acid modulates dendritic cell activation and antigen expression.
It is concluded that tumor-derived lactic acid is an important factor modulating the DC phenotype in the tumor environment, which may critically contribute to tumor escape mechanisms. Expand