A. Macho

Publications77
h-index31
Citations7,315
Highly Influential Citations195
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Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death
TLDR
Assessment of mitochondrial ROS generation provides an accurate picture of PCD-mediated lymphocyte depletion and indicates alterations of mitochondrial function constitute an important feature of early PCD.
Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
TLDR
It is shown that mitochondria contain a pre-formed approximately 50-kD protein which is released upon delta psi m disruption and which, in a cell-free in vitro system, causes isolated nuclei to undergo apoptotic changes such as chromatin condensation and internucleosomal DNA fragmentation, and the effect of Bcl-2 on the formation, release, and action of AIF.
Mitochondrial permeability transition is a central coordinating event of apoptosis
TLDR
Testing the effect of a specific inhibitor of PT, bongkrekic acid (BA), a ligand of the mitochondrial adenine nucleotide translocator, on a prototypic model of apoptosis glucocorticoid-induced thymocyte death suggests that a number of apoptotic phenomena are secondary to PT.
Caffeic Acid Phenethyl Ester Inhibits T-Cell Activation by Targeting Both Nuclear Factor of Activated T-Cells and NF-κB Transcription Factors
TLDR
The immunosuppressive activity of CAPE is evaluated in human T-cells, discovering that this phenolic compound is a potent inhibitor of early and late events in T-cell receptor-mediated T- cell activation.
Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors.
TLDR
The immunosuppressive activity of CAPE is evaluated in human T-cells, discovering that this phenolic compound is a potent inhibitor of early and late events in T-cell receptor-mediated T- cell activation.
Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents.
TLDR
Delta psi m disruption seems to be an obligatory step of early (pre-nuclear) apoptosis, and delta psi m is stabilized by two members of the bcl-2 gene family conferring resistance to chemotherapy.
Selective induction of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium
TLDR
Results provide evidence that the PMOR system may be an interesting target to design antitumoral and anti-inflammatory drugs and the implication of a possible vanilloid receptor in calcium mobilization, but not in ROS generation is presented.
Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis.
TLDR
It is shown that cells first undergo the Delta psi m disruption and that PS exposure only affects cells that already have a low delta psi m, indicating that the nucleus does not intervene in the sequence of events coupling mitochondrial dysfunction to PS exposure.
Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis.
TLDR
A two-step model of the common phase of apoptosis is suggested, where cells hyperproduce ROS with an associated disruption of Ca2+ homeostasis and at a later stage of the apoptotic process, cells manifest a near-simultaneous increase in ROS production and intracellular Ca 2+ levels.
Chloromethyl-X-Rosamine is an aldehyde-fixable potential-sensitive fluorochrome for the detection of early apoptosis.
TLDR
Chloromethyl-X-rosamine (CMXRos) is shown to be a viable alternative to other delta psi m-sensitive probes, and that it allows for formaldehyde fixation of cells before analysis, and provides several methodological advantages over other, nonfixable fluorochromes used forDelta psi m determination.
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