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Virtual screening-driven drug discovery of SARS-CoV2 enzyme inhibitors targeting viral attachment, replication, post-translational modification and host immunity evasion infection mechanisms
TLDR
Nine antiviral secondary metabolites from fungi were docked onto five SARS-CoV2 enzymes involved in viral attachment, replication, post-translational modification, and host immunity evasion infection mechanisms followed by molecular dynamics simulation and in silico ADMET prediction.
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Antitubercular constituents from Premna odorata Blanco.
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The amazing potential of fungi: 50 ways we can exploit fungi industrially
TLDR
This manuscript reviews fifty ways in which fungi can potentially be utilized as biotechnology and provides a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential products.
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Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis
TLDR
Its phytomedicinal potential to treat tuberculosis is also described, and for the first time the isolation of these constituents from A. purpurata is demonstrated.
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Antitubercular and Cytotoxic Chlorinated seco-Cyclohexenes from Uvaria alba.
Two new chlorine-containing polyoxygenated seco-cyclohexenes, albanols A (1) and B (2), along with the oxepinone metabolite grandiuvarone (3) were isolated from the endemic Philippine Annonaceae…
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In vitro angiotensin I converting enzyme inhibition by a peptide isolated from Chiropsalmus quadrigatus Haeckel (box jellyfish) venom hydrolysate.
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Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa.
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Tetrahydroxanthene-1,3(2H)-dione derivatives from Uvaria valderramensis.
TLDR
Two tetrahydroxanthene-1,3(2H)-dione metabolites, valderramenols A and B, were isolated from the Philippine endemic Annonaceous species Uvariavalderramensis and exhibited cytotoxic activity against KB-562, a chronic myeloid leukemia cell line.
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Sterols and triterpenes from the non-polar antitubercular fraction of Abutilon indicum
TLDR
The present results demonstrate the potential of Abutilon indicum as a plant source of compounds that may exhibit promising antituberculosis activity and provide sufficient reason for further study to isolate the metabolites from A. indicum responsible for the antitubercular activity.
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Glucosides from the unripe fruit juice of Carica papaya Linn. (Caricaceae) cultivar ‘Red Lady’ with antioxidant activity
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