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Genome-wide association study of major recurrent depression in the U.K. population.
This genome-wide association study using 1,636 cases of depression ascertained in the U.K. and comparison subjects screened negative for psychiatric disorders suggests that individual gene contributions to depression are likely to have only minor effects, and very large pooled analyses will be required to identify them.
Differential Activity by Polymorphic Variants of a Remote Enhancer that Supports Galanin Expression in the Hypothalamus and Amygdala: Implications for Obesity, Depression and Alcoholism
The linkage of the SNPs analysed in this study with a SNP previously associated with MDD together with the functioning of GAL5.1 as a PVN and amygdala specific enhancer represent a significant advance in the authors' ability to understand alcoholism, obesity and major depressive disorder.
A Polymorphism Associated with Depressive Disorders Differentially Regulates Brain Derived Neurotrophic Factor Promoter IV Activity
Palmitic acid triggers inflammatory responses in N42 cultured hypothalamic cells partially via ceramide synthesis but not via TLR4
Ceramide accumulation represents one on the mechanisms by which PA induces inflammation in neurons with OA and EPA being anti-inflammatory by decreasing PA-induced intracellular ceramide build-up.
A highly conserved Wnt-dependent TCF4 binding site within the proximal enhancer of the anti-myogenic Msx1 gene supports expression within Pax3-expressing limb bud muscle precursor cells.
An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome
Long-Range Regulatory Synergy Is Required to Allow Control of the TAC1 Locus by MEK/ERK Signalling in Sensory Neurones
This study provides a unique insight into the role of long-range enhancer-promoter synergy and selectivity in the tissue-specific response of promoters to specific signal transduction pathways and suggests a possible new avenue for the development of novel anti-inflammatory therapies.
Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones
- L. Shanley, M. Lear, S. Davidson, R. Ross, A. MacKenzie
- BiologyJournal of Neuroinflammation
- 4 February 2011
The diversity of mechanisms modulating the activity of the TAC1 promoter are demonstrated and provide novel directions for the development of new anti-inflammatory therapies.
Functional effects of polymorphisms on glucocorticoid receptor modulation of human anxiogenic substance-P gene promoter activity in primary amygdala neurones
In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling.
The data suggest that some fetal ovaries are affected by smoke exposure while others are not, indicating that additional studies, with larger numbers, may show more significant effects.