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Fluorescent Sensors for Measuring Metal Ions in Living Systems
BAF facilitates interphase nuclear membrane repair through recruitment of nuclear transmembrane proteins
TLDR
This work shows BAF, a nuclear envelope protein that shapes chromatin and recruits membrane proteins in mitosis, also facilitates nuclear membrane repair in interphase, in part through recruitment of the nuclear membrane proteins emerin and LEMD2 to rupture sites. Expand
Long‐term live‐cell imaging reveals new roles for Salmonella effector proteins SseG and SteA
TLDR
A pipeline for long‐term live‐cell imaging of infected cells and subsequent image analysis methods is established to track bacterial replication within the Salmonella‐containing vacuole in epithelial cells, quantify vacuolar replication versus survival in macrophages and investigate the role of individual effector proteins in mediating these parameters. Expand
BAF facilitates interphase nuclear membrane repair through recruitment of nuclear transmembrane proteins
TLDR
Depletion of the BAF interactors LEMD2 or emerin, and to a lesser extent lamin A/C, increased the duration of nucleus ruptures, consistent with LEM-protein binding being a key function of BAF during membrane repair. Expand
In Vitro and In Vivo Studies of the Utility of Dimethyl and Diethyl Carbaporphyrin Ketals in Treatment of Cutaneous Leishmaniasis
TLDR
The effectiveness and cytotoxicity of the dimethyl and diethyl carbaporphyrin ketals (CKOMe and CKOEt) were determined in vitro using pathogenic Leishmania species with and without exposure to visible light, and in vivo, the parasitic load was diminished without noticeable toxic effects. Expand
Carbaporphyrin ketals as potential agents for a new photodynamic therapy treatment of leishmaniasis.
TLDR
Dimethyl and diethyl carbaporphyrin ketals inhibit the growth of Leishmania tarentolae promastigotes in vitro and show promise as potent inhibitors of Leishesmania. Expand
Adding to the confusion! Synthesis and metalation of pyrazole analogues of the porphyrins.
TLDR
N-substituted pyrazole dialdehydes are shown to react with a tripyrrane under '3 + 1' conditions to give aza-analogues of the N-confused porphyrins to show borderline aromatic properties and readily afford organometallic derivatives with Ni(OAc)2 and Pd(Oac)2. Expand
Pyrazole analogues of porphyrins and oxophlorins.
TLDR
This work extends the understanding of carbaporphyrinoid systems and provides the first detailed studies on pyrazole-containing porphyrin analogues. Expand
Methods to Illuminate the Role of Salmonella Effector Proteins during Infection: A Review
TLDR
How different approaches have revealed mechanistic details for effectors in manipulating host cellular processes including: the dynamics of effector translocation into host cells, cytoskeleton reorganization, membrane trafficking, gene regulation, and autophagy is described. Expand
Optimized Fluorescence Complementation Platform for Visualizing Salmonella Effector Proteins Reveals Distinctly Different Intracellular Niches in Different Cell Types.
TLDR
This work provides a modular labeling platform based on fluorescence complementation with split-GFP that permits facile tagging of new Salmonella effector proteins and develops a methodology for visualizing effectors in primary macrophage cells for the first time and reveals distinct differences in the effector-defined intracellular niche between primary Macrophage and commonly used HeLa and RAW cell lines. Expand
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