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Discriminative stimulus effects of morphine: effects of training dose on agonist and antagonist effects of mu opioids.
Experiments examined how training dose of morphine modulates the agonist and antagonist effects of selected mu opioids. Saline and either 3.2 or 5.6 mg/kg morphine were established as discriminativeExpand
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In vivo apparent pA2 analysis for naltrexone antagonism of discriminative stimulus and analgesic effects of opiate agonists in rats.
Six opiate agonists were characterized by in vivo apparent pA2 analysis with respect to their discriminative stimulus, rate-decreasing and analgesic effects, by using the antagonist naltrexone. InExpand
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Tolerance to morphine-like stimulus effects of mu opioid agonists.
Experiments assessed the ability of repeated treatment with morphine to produce tolerance to morphine-like discriminative stimulus effects of buprenorphine, etorphine, methadone, morphine, andExpand
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Reinforcing and discriminative stimulus properties of mixed agonist-antagonist opioids.
Nine mixed agonist-antagonist opioids were evaluated in macaque monkeys for their ability to serve as positive reinforcers and for their discriminative stimulus similarity to etorphine andExpand
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Tolerance to drugs acting as discriminative stimuli.
The experiments described above highlight the ways behavioral and pharmacodynamic processes interact to modulate the development of tolerance to the discriminative stimulus effects of drugs. TheseExpand
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Maintenance of behavior by ketamine and related compounds in rhesus monkeys with different self-administration histories.
Rhesus monkeys lever-pressed under a fixed-ratio 30 time-out 600 sec schedule of i.v. injection of codeine (0.32 mg/kg/injection) or, in a second group of monkeys, ketamine (1.0 mg/kg/injection).Expand
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Limitations on the antagonistic actions of opioid antagonists.
This paper reviews factors that may limit or modify the behavioral actions of opioid antagonists under schedules of operant behavior in laboratory animals. The surmountable antagonism of opioidExpand
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Discriminative-stimulus effects of the low efficacy mu agonist nalbuphine.
  • E. Walker, A. M. Young
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 October 1993
The discriminative stimulus effects of nalbuphine were studied in 15 male Sprague-Dawley rats trained to discriminate 3.2 mg/kg of nalbuphine from saline under a fixed-ratio 15 schedule of foodExpand
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