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Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease.
A double-blind, randomized, clinical field trial was designed to test the efficacy and tolerance of a specific drug treatment in children in the indeterminate phase of infection by Trypanosoma cruzi.Expand
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Congenital Trypanosoma cruzi infection. Efficacy of its monitoring in an urban reference health center in a non-endemic area of Argentina.
Congenital transmission (CT) has acquired relevance in Chagas disease (CHD). A cohort of pregnant CHD women (4,355) and their babies were studied in the period 1994-2004. Children were excluded whenExpand
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Identification of major Trypanosoma cruzi antigenic determinants in chronic Chagas' heart disease.
To identify Trypanosoma cruzi target antigens in overt Chagas' heart disease, a parasite lambda gt11 cDNA library was screened with the serum of a patient with a severe chagasic heart involvementExpand
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Outcome of infection with different strains of Trypanosoma cruzi in mice lacking CD4 and/or CD8.
Mice lacking CD4 and/or CD8 gene expression, generated by embryonic stem-cell technology, were used to study the role of CD4+ and CD8+ cells in the resistance to the acute infection with virulentExpand
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Trypanosoma cruzi: specific detection of parasites by PCR in infected humans and vectors using a set of primers (BP1/BP2) targeted to a nuclear DNA sequence.
In the present work we evaluate Trypanosoma cruzi DNA detection by PCR using the nuclear oligonucleotides BP1/BP2 as primers. These primers are targeted to the 5' and 3' ends of the coding region forExpand
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Molecular cloning, sequencing and expression of a serine proteinase inhibitor gene from Toxoplasma gondii.
A cDNA clone from a Toxoplasma gondii tachyzoite cDNA library encoding a serine proteinase inhibitor (serpin) was isolated. The 1376 bp cDNA sequence encodes a 294 amino acid protein with a putativeExpand
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Purification and some properties of an acidic protease from epimastigotes of Trypanosoma cruzi
Abstract 1. 1. An acidic protease was purified to electrophoretic homogeneity (34-fold purification, 7% yield) from epimastigotes of Trypanosoma cruzi, Tulahuen strain, Tul 2 stock. The enzyme isExpand
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Predictive role of polymerase chain reaction in the early diagnosis of congenital Trypanosoma cruzi infection.
The efficacy of specific chemotherapy in congenital Chagas disease before the first year of life ranges between 90 and 100%. Between this age and 15 years of age, the efficacy decreases to aroundExpand
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Immunoprotection of mice against Trypanosoma cruzi with a lyophilized flagellar fraction of the parasite plus adjuvant.
The immunization with the flagellar (F) fraction from epimastigotes of Trypanosoma cruzi has been shown to protect mice against a challenge of bloodstream trypomastigotes of the parasite, both inExpand
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In vitro anti-parasitic activity of Cyclosporin A analogs on Trypanosoma cruzi.
Cyclosporin A (CsA) nonimmunosuppressive analogs were evaluated against Trypanosoma cruzi and on TcCyP19, a cyclophilin of 19 kDa. Two out of eight CsA analogs, H-7-94 and F-7-62 showed the bestExpand
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