A. M. Rossi

Publications30
h-index11
Citations633
Highly Influential Citations30
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Structural and functional conservation of key domains in InsP3 and ryanodine receptors
Inositol-1,4,5-trisphosphate receptors (InsP3Rs) and ryanodine receptors (RyRs) are tetrameric intracellular Ca2+ channels. In each of these receptor families, the pore, which is formed by… Expand
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Analysis of protein-ligand interactions by fluorescence polarization
Quantification of the associations between biomolecules is required both to predict and understand the interactions that underpin all biological activity. Fluorescence polarization (FP) provides a… Expand
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CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions
Calcium-binding protein 1 (CaBP1) is a neuron-specific member of the calmodulin superfamily that regulates several Ca2+ channels, including inositol 1,4,5-trisphosphate receptors (InsP3Rs). CaBP1… Expand
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Subtype-selective regulation of IP3 receptors by thimerosal via cysteine residues within the IP3-binding core and suppressor domain
IP3R (IP3 [inositol 1,4,5-trisphosphate] receptors) and ryanodine receptors are the most widely expressed intracellular Ca2+ channels and both are regulated by thiol reagents. In DT40 cells stably… Expand
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Structural organization of signalling to and from IP3 receptors.
In the 30 years since IP3 (inositol 1,4,5-trisphosphate) was first shown to release Ca2+ from intracellular stores, the importance of spatially organized interactions within IP3-regulated signalling… Expand
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Synthetic partial agonists reveal key steps in IP3 receptor activation
Inositol 1,4,5-trisphosphate receptors (IP3R) are ubiquitous intracellular Ca2+ channels. IP3binding to the IP3-binding core (IBC) near the N-terminal initiates conformational changes that lead to… Expand
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Binding of Inositol 1,4,5-trisphosphate (IP3) and Adenophostin A to the N-Terminal region of the IP3 Receptor: Thermodynamic Analysis Using Fluorescence Polarization with a Novel IP3 Receptor Ligand
Inositol 1,4,5-trisphosphate (IP3) receptors (IP3R) are intracellular Ca2+ channels. Their opening is initiated by binding of IP3 to the IP3-binding core (IBC; residues 224–604 of IP3R1) and… Expand
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Adenophostins: High-Affinity Agonists of IP(3) Receptors.
Publisher Summary Adenophostins are naturally occurring high-affinity agonists of inositol 1,4,5-trisphosphate receptors (IP3R). The three components of adenophostin—bisphosphorylated glucose,… Expand
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Selective determinants of inositol 1,4,5-trisphosphate and adenophostin A interactions with type 1 inositol 1,4,5-trisphosphate receptors
BACKGROUND AND PURPOSE Adenophostin A (AdA) is a potent agonist of inositol 1,4,5‐trisphosphate receptors (IP3R). AdA shares with IP3 the essential features of all IP3R agonists, namely structures… Expand
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Activation of IP3 receptors requires an endogenous 1-8-14 calmodulin-binding motif
Binding of IP3 (inositol 1,4,5-trisphosphate) to the IP3-binding core (residues 224–604) of IP3Rs (IP3 receptors) initiates opening of these ubiquitous intracellular Ca2+ channels. The mechanisms are… Expand
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