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The assessment of antagonist potency under conditions of transient response kinetics.
The muscarinic acetylcholine receptor antagonists, atropine and pirenzepine, produced an apparent insurmountable antagonism of muscarinic M(1) receptor-mediated intracellular Ca(2+) mobilization inExpand
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Neurokinin receptors and mucosal ion transport in porcine jejunum.
Neurokinin (NK) peptides such as substance P (SP) may modulate epithelial ion transport in the small intestine. The present study was undertaken to examine the pharmacological mechanisms by which SPExpand
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Pharmacological analysis of the novel mode of interaction between xanomeline and the M1 muscarinic acetylcholine receptor.
Previous findings in our laboratory suggested that the M1 muscarinic acetylcholine receptor (mAChR) agonist xanomeline exhibits a novel mode of interaction that involves persistent binding to andExpand
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Spinal NK1 receptors contribute to the increased excitability of the nociceptive flexor reflex during persistent peripheral inflammation
Hyperalgesia is a characteristic of inflammation and is mediated, in part, by an increase in the excitability of spinal neurons. Although substance P does not appear to mediate fast synaptic eventsExpand
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Progressive cancellous bone loss in rats after adrenalectomy and oophorectomy
SummaryFemale Sprague-Dawley rats (n=72), 6 months old, underwent either sham operation, oophorectomy, adrenalectomy, or combined oophorectomy and adrenalectomy (O&A). They were all maintained onExpand
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Substance P produces sodium and bicarbonate secretion in porcine jejunal mucosa through an action on enteric neurons.
The neuropeptide substance P (SP) produces transient elevations in short-circuit current (Isc), a measure of active ion transport, across sheets of small intestinal mucosae from several animalExpand
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Actions of neuropeptide Y on basal, cyclic AMP-induced and neurally evoked ion transport in porcine distal jejunum
Neuropeptide Y (NPY) and its homolog, peptide YY, are present respectively in neurons and endocrine cells within the mammalian small intestine. In this study, we examined the actions of NPY on ionExpand
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Tachykinins alter inositol phosphate formation, but not cyclic AMP levels, in primary cultures of neonatal rat spinal neurons through activation of neurokinin receptors
The naturally occurring tachykinins, substance P, neurokinin A and neurokinin B, induce the formation of inositol phosphates or cAMP in a variety of tissues but their effects on neurons have not beenExpand
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Effects of galanin on smooth muscle and mucosa of porcine jejunum
The enteric neuropeptide galanin (GAL) increased the amplitude of spontaneous contractions in longitudinally oriented muscle strips and inhibited short-circuit current (Isc) elevations induced byExpand
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Calcitonin gene‐related peptide induces the formation of second messengers in primary cultures of neonatal rat spinal cord
This study investigated second messengers formed in response to calcitonin gene‐related peptide (CGRP) in primary cultures of neonatal rat spinal cord. CGRP increased the level of cAMP above basalExpand
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