A. M. Macleod

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Marcus E. Raichle, A. M. Macleod, Abraham Z. Snyder, Winslow Powers, Debra A. Gusnard, Gordon L. Shulman
Proceedings of the National Academy of Sciences…
2001

A baseline or control state is fundamental to the understanding of most complex systems. Defining a baseline state in the human brain, arguably our most complex system, poses a particular challenge.… (More)

Markus Raichle, Julie A. Fiez, +4 authors S. E. Petersen
Cerebral cortex
1994

Practice of a novel task leads to improved performance. The brain mechanisms associated with practice-induced improvement in performance are largely unknown. To address this question we have examined… (More)

An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition.

G. R. Dawson, Karen A. Maubach, +14 authors John R. Atack
The Journal of pharmacology and experimental…
2006

Alpha5IA is a compound that binds with equivalent subnanomolar affinity to the benzodiazepine (BZ) site of GABA(A) receptors containing an alpha1, alpha2, alpha3, or alpha5 subunit but has inverse… (More)

Tactile attention tasks enhance activation in somatosensory regions of parietal cortex: a positron emission tomography study.

Harold Burton, Nicholas S. Abend, A. M. Macleod, Rodney Sinclair, Abraham Z. Snyder, Markus Raichle
Cerebral cortex
1999

We used positron emission tomography to study cortical regions mediating tactile attention. Cues selectively directed subjects to attend to the roughness or duration of contact with embossed gratings… (More)

Multiple foci in parietal and frontal cortex activated by rubbing embossed grating patterns across fingerpads: a positron emission tomography study in humans.

Hannah M.M. Burton, A. M. Macleod, Tom O. Videen, Markus Raichle
Cerebral cortex
1997

Somatosensory representations occupy parietal postcentral gyral (S1) and lateral sulcal-opercular cortex (S2). To address the issue of possible multiple activation foci in these regions and possible… (More)

An Inverse Agonist Selective for 5 Subunit-Containing GABAA Receptors Enhances Cognition

G. R. Dawson, Karen A. Maubach, +14 authors John R. Atack
2005

5IA is a compound that binds with equivalent subnanomolar affinity to the benzodiazepine (BZ) site of GABAA receptors containing an 1, 2, 3, or 5 subunit but has inverse agonist efficacy selective… (More)

High quality electron beams from a laser wakefield accelerator

S M Wiggins, R. P. Shanks, +13 authors D. A. Jaroszynski
CLEO/QELS: 2010 Laser Science to Photonic…
2004

Very stable, high quality electron beams (current ∼ 10 kA, energy spread < 1%, emittance ∼ 1π mm mrad) have been generated in a laser-plasma accelerator driven by 25 TW… (More)

Intermittent versus continuous renal replacement therapy for acute renal failure in adults.

Kannaiyan Samuel Rabindranath, J. Adams, A. M. Macleod, Nicola Muirhead
The Cochrane database of systematic reviews
2007

BACKGROUND Renal replacement therapy (RRT) for acute renal failure (ARF) can be applied intermittently (IRRT) or continuously (CRRT). It has been suggested that CRRT has several advantages over IRRT… (More)

Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets.

Frederick D Tattersall, Wayne Rycroft, +13 authors Robert H J Hargreaves
Neuropharmacology
1996

These studies have compared the pharmacological profile of two non-peptide human type neurokinin1 (hNK1) receptor selective antagonists, L-741,671 and a quaternised compound L-743,310. In radioligand… (More)

Chronic renal failure: factors influencing nephrology referral.

I. H. Khan, Graham Catto, Nikhil B. Edward, A. M. Macleod
QJM : monthly journal of the Association of…
1994

Factors influencing referral of all 304 patients who developed persistent renal failure during one year were studied in the stable Grampian population. The annual incidence of chronic renal failure… (More)

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