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Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.
The 26S proteasome is essential for the proteolysis of proteins that have been covalently modified by the attachment of polyubiquitinated chains. Although the 20S core particle performs theExpand
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DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a
The Rad23 family of proteins, including the human homologs hHR23a and hHR23b, stimulates nucleotide excision repair and has been shown to provide a novel link between proteasome-mediated proteinExpand
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The role of mutant p53 in human cancer
Mutations in the TP53 (p53) gene are present in a large fraction of human tumours, which frequently express mutant p53 proteins at high but heterogeneous levels. The clinical significance of thisExpand
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Stapled peptides with improved potency and specificity that activate p53.
By using a phage display derived peptide as an initial template, compounds have been developed that are highly specific against Mdm2/Mdm4. These compounds exhibit greater potency in p53 activationExpand
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Ubiquitin recognition by the DNA repair protein hHR23a.
Ubiquitin is a prominent regulatory protein in numerous biological processes, including targeted protein degradation, endocytic sorting, transcriptional control, intranuclear localization, andExpand
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Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.
The number of newly formed neurons declines rapidly during aging, and this decrease in neurogenesis is associated with decreased function of neural stem/progenitor cells (NPCs). Here, we determinedExpand
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  • Open Access
A unique role for p53 in the regulation of M2 macrophage polarization
P53 is critically important in preventing oncogenesis but its role in inflammation in general and in the function of inflammatory macrophages in particular is not clear. Here, we show that boneExpand
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Ubiquitin family proteins and their relationship to the proteasome: a structural perspective.
Many biological processes rely on targeted protein degradation, the dysregulation of which contributes to the pathogenesis of various diseases. Ubiquitin plays a well-established role in thisExpand
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  • Open Access
Ionizing radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafish
Mutant p53 proteins accumulate to high levels in human tumors and in preneoplastic lesions in the skin and fallopian tube. However examination of tissues from mice and fish that are homozygous forExpand
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Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins
BackgroundThe delivery of ubiquitinated proteins to the proteasome for degradation is a key step in the regulation of the ubiquitin-proteasome pathway, yet the mechanisms underlying this step are notExpand
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  • Open Access