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Tumor‐induced myeloid‐derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8+ T‐cell activation events
Tumor growth coincides with an accumulation of myeloid‐derived suppressor cells (MDSCs), which exert immune suppression and which consist of two main subpopulations, known as monocytic (MO)Expand
G-CSF stem cell mobilization in human donors induces polymorphonuclear and mononuclear myeloid-derived suppressor cells.
The role of myeloid-derived suppressor cells (MDSC) is emerging in transplantation. An expansion of myeloid progenitor cells with suppressive capacity has been reported to occur as a bystanderExpand
Subset characterization of myeloid-derived suppressor cells arising during induction of BM chimerism in mice
To date, myeloid-derived suppressor cells (MDSC) have been best studied in cancer, where they represent an escape mechanism for immune surveillance. MDSC are now also gaining interest in the contextExpand
Clinical relevance of measurement of antibodies to individual snU1-RNP proteins.
Anti-ribonucleoprotein (RNP) antibodies are found in mixed connective tissue disease (MCTD), a syndrome characterized by features of systemic lupus erythematosus (SLE), inflammatory muscle disease,Expand
Human Multipotent Adult Progenitor Cells Are Nonimmunogenic and Exert Potent Immunomodulatory Effects on Alloreactive T-Cell Responses
Multipotent adult progenitor cells (MAPCs) are bone marrow-derived nonhematopoietic stem cells with a broad differentiation potential and extensive expansion capacity. A comparative study betweenExpand
Antibodies to extractable nuclear antigens in antinuclear antibody-negative samples.
Antibodies to extractable nuclear antigens (ENAs)—SSA, SSB, U1RNP, Sm, Scl-70, and Jo-1—are clinically important in patients with systemic rheumatic diseases. Indirect immunofluorescence (IIF) withExpand
Oct4-negative multipotent adult progenitor cells and mesenchymal stem cells as regulators of T-cell alloreactivity in mice.
Multipotent adult progenitor cells (MAPC) are clinically being explored as an alternative to mesenchymal stem cells (MSC) for the immunomodulatory control of graft-versus-host disease (GvHD). Here,Expand
Angioplastic necrolytic migratory erythema. Unique association of necrolytic migratory erythema, extensive angioplasia, and high molecular weight glucagon-like polypeptide.
A diabetic patient developed necrolytic migratory erythema with extensive angioplasia and high molecular weight glucagon-like polypeptide. There was no associated neoplasm such as glucagonoma.Expand
Subclinical GvHD in non-irradiated F1 hybrids: severe lymphoid-tissue GvHD causing prolonged immune dysfunction
GvHD is an important complication of allogeneic hematopoietic SCT. Parent-in-F1 models are frequently used to study GvHD immunobiology; the characteristics of parent-in-F1 GvHD vary between strainExpand
Mouse MAPC-mediated immunomodulation: Cell-line dependent variation.
Adoptive therapy with mesenchymal stem cells (MSC) is being developed as a promising approach in the treatment of graft-vs-host disease (GVHD). In vitro, MSC exhibit strong immunomodulatoryExpand