• Publications
  • Influence
Chemokines--chemotactic cytokines that mediate inflammation.
  • A. Luster
  • Biology, Medicine
    The New England journal of medicine
  • 12 February 1998
This review introduces the burgeoning family of cytokines, with special emphasis on their role in the pathophysiology of disease and their potential as targets for therapy.
Toll-like receptors stimulate human neutrophil function.
Using quantitative polymerase chain reaction (QPCR), a chemokine expression profile is demonstrated that suggests that TLR-stimulated neutrophils recruit innate, but not acquired, immune cells to sites of infection.
CXCR3 ligands: redundant, collaborative and antagonistic functions
How the balance, timing and pattern of CXCR3 ligand expression appears to regulate the generation of effector T cells in the lymphoid compartment and subsequent migration into peripheral sites of Th1‐type inflammation is discussed.
γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins
The molecular cloning and characterization of a gene regulated by rIFN-γ in U937 cells as well as in human mononuclear cells, fibroblasts and endothelial cells is reported here and may be a member of a family of proteins involved in the inflammatory process.
Chemokines and chemokine receptors: positioning cells for host defense and immunity.
This review focuses on recent advances in understanding how the chemokine system orchestrates immune cell migration and positioning at the organismic level in homeostasis, in acute inflammation, and during the generation and regulation of adoptive primary and secondary immune responses in the lymphoid system and peripheral nonlymphoid tissue.
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.
It is shown that DNA-containing immune complexes within lupus serum, but not protein-containing ICs from other autoimmune rheumatic diseases, stimulates plasmacytoid DCs to produce cytokines and chemokines via a cooperative interaction between Toll-like receptor 9 (TLR9) and FcgammaRIIa (CD32).
Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2)
Monocyte recruitment to the central nervous system (CNS) is a necessary step in the development of pathologic inflammatory lesions in experimental autoimmune encephalomyelitis (EAE), a murine model
Immune cell migration in inflammation: present and future therapeutic targets
The challenge for the future will be to identify the trafficking molecules that will most specifically inhibit the key subsets of cells that drive disease processes without affecting the migration and function of leukocytes required for protective immunity.
Orchestrating the orchestrators: chemokines in control of T cell traffic
Advances in understanding of how chemokines orchestrate the trafficking and activity of immune cells has increased considerably are reviewed with particular emphasis on control of the migration of T cell subsets in lymph nodes and in peripheral tissues in homeostasis and inflammation.
Chemokines and their receptors: drug targets in immunity and inflammation.
  • A. Viola, A. Luster
  • Biology, Medicine
    Annual review of pharmacology and toxicology
  • 9 January 2008
The role of chemokines in health and diseases is examined, strategies to target the chemokine system are discussed, and several promising drugs are currently being tested in late-stage clinical trials.