• Publications
  • Influence
ADAMTS1/METH1 Inhibits Endothelial Cell Proliferation by Direct Binding and Sequestration of VEGF165*
It is demonstrated that ADAMTS1 significantly blocks VEGFR2 phosphorylation with consequent suppression of endothelial cell proliferation and is described as a novel modulator of VEGF bioavailability. Expand
Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells
Matrix-bound VEGF elicits more distinct vascular effects than soluble VEGF, including prolonged VEGFR2 activation with altered patterns of tyrosine activation and downstream enhancement of theExpand
Activated Conformations of Very Late Activation Integrins Detected by a Group of Antibodies (HUTS) Specific for a Novel Regulatory Region(355425) of the Common 1 Chain (*)
Interestingly, binding of HUTS mAbs to partially activated VLA integrins results in maximal activation of these adhesion receptors and enhancement of cell adhesion to β1 integrin ligands collagen, laminin, and fibronectin. Expand
ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1.
A new functional role for the ERMs (ezrin/radixin/moesin) as adaptor molecules in the interactions of adhesion receptors and intracellular tyrosine kinases is unveiled and it is shown that PSGL-1 is a signaling molecule in leukocytes. Expand
Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism.
It is demonstrated that beta1 integrin functions upstream of Par3 as part of a molecular cascade required for endothelial cell polarity and lumen formation. Expand
ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors.
Their results demonstrated that human ADAMTS1 cleaves aggrecan at a previously shown site by its mouse homolog, but the authors have also identified additional cleavage sites that ultimately confirm the classification of this protease as an 'aggrecanase'. Expand
Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game
The immunobiology of TAMs as well as what is known about tumor suppressors in the context of immune responses are provided, and recent advances regarding the role of the tumor suppressor ARF as a regulator of inflammation and macrophage polarization are reviewed. Expand
Fibulin-1 Acts as a Cofactor for the Matrix Metalloprotease ADAMTS-1*
Findings indicate that fibulin-1 is a new regulator of ADAMTS-1-mediated proteoglycans proteolysis and thus may play an important role in proteoglycan turnover in tissues where there is overlapping expression. Expand
The interaction of activated integrin lymphocyte function-associated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and
It is demonstrated that interaction of the beta2-integrin LFA-1 with its ligand intercellular adhesion molecule 1 induces remodeling of T lymphocyte morphology and activation and redistribution of the cytoplasmic tyrosine kinases FAK and PYK-2. Expand
Chemokines and relapses in childhood acute lymphoblastic leukemia: A role in migration and in resistance to antileukemic drugs.
CXCR3 signaling in ALL may have a dual function: chemotactic for the localisation of leukemic blasts in specific niches, and it may also confer resistance to chemotherapy, enhancing the chances for relapses. Expand