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Cell death: apoptosis versus necrosis (review).
Cell death and the subsequent post-mortem changes, called necrosis, are integral parts of normal development and maturation cycle. Despite the importance of this process, the mechanisms underlyingExpand
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Molecular mimicry of phage displayed peptides mimicking GD3 ganglioside
We have analyzed sequence homologies between nonimmunogenic phage displayed peptides mimicking GD3 ganglioside and human/mouse self-proteins. The GD3 ganglioside phagotopes showed homology toExpand
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Possible association between HPV16 E7 protein level and cytokeratin 19
The mechanisms employed by human papillomaviruses (HPVs) to control the replication of the viral genome and the expression of the viral genes are extremely complex and further complicated by the factExpand
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Individuation of monoclonal anti-HPV16 E7 antibody linear peptide epitope by computational biology
We applied computational biology to identify the linear amino acid sequence recognized by a mouse monoclonal antibody raised against the full length HPV16 E7 oncoprotein. Computer-assisted search forExpand
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Computational peptide dissection of Melan-a/MART-1 oncoprotein antigenicity
We have mapped the linear antigenic determinant of a commercial MAb raised in the mouse against the melanoma-associated-antigen Melan-A/MART-1. The B cell epitope on the Melan-A/MART-1 oncoprotein isExpand
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Designing a peptide-based vaccine against Porphyromonas gingivalis.
Using proteome databases and exploiting the concept that a rare sequence is a potential epitope, epitopic sequences derived from Porphyromonas gingivalis fimA type I protein were examined forExpand
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Computer‐assisted analysis of molecular mimicry between human papillomavirus 16 E7 oncoprotein and human protein sequences
The immunology of human papillomavirus (HPV) infections has peculiar characteristics. The long latency for cervical cancer development after primary viral infection suggests mechanisms that may aidExpand
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Monoclonal and polyclonal humoral immune response to EC HER‐2/NEU peptides with low similarity to the host's proteome
We are studying peptide immunogenicity as a function of the similarity level to the host's proteome. By using as a model the breast/prostate cancer‐associated HER‐2/neu antigen, we analyzed theExpand
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Role of MHC II affinity and molecular mimicry in defining anti-HER-2/neu MAb-3 linear peptide epitope
With the aid of computational biology, we have studied the possibility of predicting the peptides able to evoke humoral immune response by using as experimental model the human HER-2/neu breastExpand
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Non-redundant peptidomes from DAPs: towards "the vaccine"?
Experimental analyses and literature survey reveal low-redundancy to the host proteins as a common denominator of immunogenic sequences mapped along tumor-, autoimmune-, and infectiousExpand
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