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Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.
- C. Granchi, Sarabindu Roy, +15 authors F. Minutolo
- Chemistry, Medicine
- Journal of medicinal chemistry
- 18 February 2011
Highly invasive tumor cells are characterized by a metabolic switch, known as the Warburg effect, from "normal" oxidative phosphorylation to increased glycolysis even under sufficiently oxygenated… Expand
The trace element content of top-soil and wild edible mushroom samples collected in Tuscany, Italy
- G. Giannaccini, L. Betti, +7 authors A. Lucacchini
- Medicine, Chemistry
- Environmental Monitoring and Assessment
- 29 February 2012
The amount of the trace elements As, Ba, Cd, Cr, Cu, Hg, Li, Mn, Ni, Pb, Rb, Se, Sr, and Zn was measured in top soils and edible mushrooms, Boletus edulis, Macrolepiota procera, collected at five… Expand
Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromes
IntroductionA growing interest has arisen in salivary proteomics as a tool for the identification of biomarkers for primary Sjögren's syndrome (pSS). Nonetheless, only a limited number of preclinical… Expand
Isolation of putative benzodiazepine receptors from rat brain membranes by affinity chromatography.
- C. Martini, A. Lucacchini, G. Ronca, S. Hrelia, C. Rossi
- Chemistry, Medicine
- Journal of neurochemistry
The benzodiazepine receptor from rat brain was solubilised and purified 5200-fold by affinity chromatography. The affinity column contained an immobilized benzodiazepine (delorazepam) and biospecific… Expand
Changes in peripheral benzodiazepine receptors in patients with panic disorder and obsessive-compulsive disorder.
Peripheral benzodiazepine (BDZ) receptors were investigated through the binding of the specific ligand 3H-PK-11195 to platelet membranes, in 17 patients suffering from panic disorder (PD) and in 16… Expand
Proteomic studies of formalin-fixed paraffin-embedded tissues
Formalin-fixed paraffin-embedded (FFPE) tissue specimens represent a valuable informational resource of histologically characterized specimens for proteomic studies. In this article, the authors… Expand
Specific proteins identified in whole saliva from patients with diffuse systemic sclerosis.
OBJECTIVE To evaluate the global changes of salivary protein profiles in patients with systemic sclerosis (SSc) using a proteomic approach. METHODS Whole saliva (WS) was collected from 15 patients… Expand
Impaired glutathione reductase activity and levels of collagenase and elastase in synovial fluid in rheumatoid arthritis.
- L. Bazzichi, M. Ciompi, +5 authors A. Lucacchini
- Clinical and experimental rheumatology
- 1 November 2002
OBJECTIVE To test the activity of elastase, collagenase and glutathione reductase in the synovial fluid (SF) of patients with rheumatoid arthritis (RA) and in patients with osteoarthritis (OA); to… Expand
Proteome analysis of whole saliva: a new tool for rheumatic diseases--the example of Sjögren's syndrome.
Sjögren's syndrome (pSS) is a systemic disease that affects salivary glands directly, and is therefore expected to influence the composition of human whole saliva (WS) fluid. The aim of this study… Expand
Agonist‐Induced Internalization and Recycling of the Human A3 Adenosine Receptors
Abstract: A3 adenosine receptors have been proposed to play an important role in the pathophysiology of cerebral ischemia with a regimen‐dependent nature of the therapeutic effects probably related… Expand