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In vitro antiplasmodial activity and cytotoxicity of ethnobotanically selected South African plants.
TLDR
Bark and leaves of 20 extracts from 14 South African plant species were tested for in vitro antiplasmodial activity by means of the flow cytometric test and the most active extract of each species giving more than 70% inhibition was selected for determination of IC(50) values. Expand
Co-inhibition of Plasmodium falciparum S-Adenosylmethionine Decarboxylase/Ornithine Decarboxylase Reveals Perturbation-specific Compensatory Mechanisms by Transcriptome, Proteome, and Metabolome
TLDR
The results provide evidence that P. falciparum responds to alleviate the detrimental effects of polyamine depletion via regulation of its transcriptome and subsequently the proteome and metabolome. Expand
MADIBA: A web server toolkit for biological interpretation of Plasmodium and plant gene clusters
TLDR
MADIBA (MicroArray Data Interface for Biological Annotation) facilitates the assignment of biological meaning to gene expression clusters by automating the post-processing stage and is an integrated, online tool that will assist researchers in interpreting their results and understand the meaning of the co-expression of a cluster of genes. Expand
Savignygrin, a Platelet Aggregation Inhibitor from the Soft TickOrnithodoros savignyi, Presents the RGD Integrin Recognition Motif on the Kunitz-BPTI Fold*
TLDR
This is the first report of a platelet aggregation inhibitor that presents the RGD motif using the Kunitz-BPTI protein fold, and indicates the specificity of savignygrin toward αIIbβ3. Expand
Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities
TLDR
In the present review, the current knowledge of unique properties of polyamine metabolism in these parasites is outlined, including prozyme regulation of AdoMetDC (S-adenosylmethionine decarboxylase) activity in trypanosomatids, and formation of trypanothione, a unique compound linking polyamine and thiol metabolism intrypanosomeids. Expand
Cloning, nucleotide sequence and expression of the gene encoding factor Xa inhibitor from the salivary glands of the tick, Ornithodoros savignyi
TLDR
The authentic nucleotide sequence of the gene encoding tick fXaI enables studies at the genetic level and probing of other tick species for similar and related genes and aids further investigations of its potential for therapeutic applications and as vaccine against tick infestation. Expand
Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions.
TLDR
Interference with essential protein-protein interactions mediated by parasite-specific regions therefore appears to be a viable strategy to aid the design of selective inhibitors of polyamine metabolism of P. falciparum. Expand
Novel properties of malarial S-adenosylmethionine decarboxylase as revealed by structural modelling.
TLDR
Internal basic residues are found to assume the role of putrescine, based on the model and site-directed mutagenesis: Arg11 is absolutely required for normal activity, while disrupting Lys15 and Lys215 each cause 50% inhibition of AdoMetDC activity. Expand
Comparative properties of a three‐dimensional model of Plasmodium falciparum ornithine decarboxylase
TLDR
The predicted PfODC homology model is consistent with mutagenesis results and biochemical studies concerning the active site residues and areas involved in stabilizing the dimeric form of the protein. Expand
Evolution of hematophagy in ticks: common origins for blood coagulation and platelet aggregation inhibitors from soft ticks of the genus Ornithodoros.
TLDR
Comparison with hemostatic inhibitors of hard ticks suggests that the two main tick families have independently evolved novel antihemostatic mechanisms, and independent evolution of these mechanisms in ticks points to a rapid divergence between tick families that could be dated between 120 and 92 MYA, which suggests this event might have been a driving force in the evolution of hematophagy in ticks. Expand
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