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The causal relation between human papillomavirus and cervical cancer.
It is the right time for medical societies and public health regulators to consider the causal role of human papillomavirus infections in cervical cancer and to define its preventive and clinical implications.
The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice.
HPV screening that distinguishes HPV16 and HPV18 from other oncogenic HPV types may identify women at the greatest risk of > or = CIN3 and may permit less aggressive management of other women with onCogenic HPV infections.
Human papillomavirus infection of the cervix: relative risk associations of 15 common anogenital types.
During the years 1982-1989, 2627 women were recruited into eight studies analyzing the relationship between human papillomavirus (HPV) infection and cervical neoplasia, and each cervical sample was rescreened for HPV DNA by low-stringency Southern blot hybridization.
Incidence, clearance and predictors of human papillomavirus infection in women.
BACKGROUND Persistent infection with carcinogenic human papillomavirus (HPV) is linked to high-grade lesions and cervical cancer. To better understand the natural history of HPV, we sought to
Comparison of self-collected vaginal, vulvar and urine samples with physician-collected cervical samples for human papillomavirus testing to detect high-grade squamous intraepithelial lesions.
Self-collection of samples for HPV testing was acceptable to women attending a colposcopy clinic for investigation of suspected cervical lesions and shows sufficient sensitivity to warrant further evaluation as a screening test for cervical cancer prevention programs.
HPV co-factors related to the development of cervical cancer: results from a population-based study in Costa Rica
We examined factors associated with high-grade squamous intraepithelial lesions (HSIL) and cervical cancer among human papillomavirus (HPV)-infected women in a prevalent case–control study conducted
The acceptability of self-collected samples for HPV testing vs. the pap test as alternatives in cervical cancer screening.
Self-sampling is more acceptable than the Pap test and could improve coverage rates of early detection programs and the incorporation of self-collected samples to detect HPV could encourage participation in screening programs among those women who reject the Paptest because of the necessary pelvic examination.
Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.
It is demonstrated that oncogenic E6 can disrupt an important cellular response to DNA damage mediated by p53 and may contribute to the subsequent accumulation of genetic changes associated with cervical tumorigenesis.
Use of a hybrid capture assay of self-collected vaginal swabs in rural Uganda for detection of human papillomavirus.
The higher prevalence and intensity of HPV infection in HIV-positive women could facilitate HPV transmission in this population of women, and self-collected vaginal swabs could be used in population-based screening to identify women at high risk of cervical neoplasia.