The causal relation between human papillomavirus and cervical cancer.
- F. X. Bosch, A. Lorincz, N. Muñoz, C. Meijer, K. Shah
- MedicineJournal of Clinical Pathology
- 1 April 2002
It is the right time for medical societies and public health regulators to consider the causal role of human papillomavirus infections in cervical cancer and to define its preventive and clinical implications.
The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice.
- Michelle J. Khan, P. Castle, M. Schiffman
- Medicine, BiologyJournal of the National Cancer Institute
- 20 July 2005
HPV screening that distinguishes HPV16 and HPV18 from other oncogenic HPV types may identify women at the greatest risk of > or = CIN3 and may permit less aggressive management of other women with onCogenic HPV infections.
A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China.
Baseline cytology, human papillomavirus testing, and risk for cervical neoplasia: a 10-year cohort analysis.
Positive combined test results should provide added reassurance for lengthening the screening interval among low-risk women, whereas positive results identify a relatively small subgroup that requires more frequent surveillance.
Human papillomavirus infection of the cervix: relative risk associations of 15 common anogenital types.
- A. Lorincz, R. Reid, A. B. Jenson, M. Greenberg, W. Lancaster, R. Kurman
- Medicine, BiologyObstetrics and Gynecology
- 1 March 1992
During the years 1982-1989, 2627 women were recruited into eight studies analyzing the relationship between human papillomavirus (HPV) infection and cervical neoplasia, and each cervical sample was rescreened for HPV DNA by low-stringency Southern blot hybridization.
HPV DNA testing of self-collected vaginal samples compared with cytologic screening to detect cervical cancer.
Results indicate that HPV testing of self-collected vaginal swabs is less specific than but as sensitive as Papanicolaou smears for detecting high-grade cervical disease in women aged 35 years and older, and HPV testing offers an important new way to increase screening in settings where cytology is not readily performed.
Incidence, clearance and predictors of human papillomavirus infection in women.
- J. Sellors, T. Karwalajtys, A. Lorincz
- MedicineCMAJ : Canadian Medical Association journal…
- 18 February 2003
BACKGROUND Persistent infection with carcinogenic human papillomavirus (HPV) is linked to high-grade lesions and cervical cancer. To better understand the natural history of HPV, we sought to…
Use of a hybrid capture assay of self-collected vaginal swabs in rural Uganda for detection of human papillomavirus.
The higher prevalence and intensity of HPV infection in HIV-positive women could facilitate HPV transmission in this population of women, and self-collected vaginal swabs could be used in population-based screening to identify women at high risk of cervical neoplasia.
Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.
- T. Kessis, R. Slebos, K. Cho
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 May 1993
It is demonstrated that oncogenic E6 can disrupt an important cellular response to DNA damage mediated by p53 and may contribute to the subsequent accumulation of genetic changes associated with cervical tumorigenesis.
Shanxi Province Cervical Cancer Screening Study: a cross-sectional comparative trial of multiple techniques to detect cervical neoplasia.
A cervical cancer screening algorithm for the developing world that is highly sensitive for cervical intraepithelial neoplasia (CIN) II, III, and cancer and highly specific for CIN II and III, making it possible to ablate the transformation zone without histologic confirmation is designed.