Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’
Light is shed on the frequency of asymptomatic SARS-CoV-2 infection, their infectivity (as measured by the viral load) and the insights into its transmission dynamics and the efficacy of the implemented control measures are provided.
Suppression of COVID-19 outbreak in the municipality of Vo, Italy
New light is shed on the frequency of asymptomatic SARS-CoV-2 infection and their infectivity (as measured by the viral load) and new insights are provided into its transmission dynamics, the duration of viral load detectability and the efficacy of the implemented control measures.
A Point Mutation in a Herpesvirus Polymerase Determines Neuropathogenicity
It is demonstrated that a single amino acid variation in a herpesvirus enzyme can influence neuropathogenic potential without having a major effect on virus shedding from infected animals, which is important for horizontal spread in a population.
Drug Repurposing for Viral Infectious Diseases: How Far Are We?
The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer.
The empirical antibiotic treatment of nosocomial spontaneous bacterial peritonitis: Results of a randomized, controlled clinical trial
The combination of meropenem plus daptomycin is more effective than ceftazidime as empirical antibiotic treatment of nosocomial SBP and is a strong predictor of 90‐day survival in patients with nosocomials SBP.
Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase
- G. Muratore, L. Goracci, A. Loregian
- BiologyProceedings of the National Academy of Sciences
- 2 April 2012
The identification of small molecule compounds able to effectively and specifically inhibit growth of influenza A and B viruses in cultured cells through targeting an assembly interface of the viral RNA-dependent RNA polymerase are reported.
Identification of new Th peptides from the cytomegalovirus protein pp65 to design a peptide library for generation of CD4 T cell lines for cellular immunoreconstitution.
These procedures based on peptide stimulation can facilitate implementation of adoptive reconstitution of CD4 responses in immunocompromised patients also in the case when the HSC allodonor is available for generation of the T cell line.
Early inhibitors of human cytomegalovirus: State-of-art and therapeutic perspectives
The Human Cytomegalovirus DNA Polymerase Processivity Factor UL44 Is Modified by SUMO in a DNA-Dependent Manner
It is shown that overexpression of SUMO alters the intranuclear distribution of UL44 in HCMV-infected cells, and enhances both virus production and DNA replication, arguing for an important role for sumoylation in H CMV life cycle and UL44 function(s).