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The role of the habenula in the transition from reward to misery in substance use and mood disorders
The habenula (Hb) is an evolutionary well-conserved structure located in the epithalamus. The Hb receives inputs from the septum, basal ganglia, hypothalamus, anterior cingulate and medial prefrontalExpand
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Skin disorders in chronic psychiatric illness
Background  Chronic psychiatric patients are prone to develop skin diseases. However, epidemiological data are scarce.
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Visualizing pharmacological activities of antidepressants: A novel approach
Antidepressants have different receptor binding profiles, which are related to therapeutic action and adverse drug reactions. We constructed a model to classify antidepressants on the basis of theirExpand
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Lack of drug interactions between mirtazapine and risperidone in psychiatric patients: a pilot study
An open-label, non-randomized, pilot study has been performed in inpatients in need of treatment with an antipsychotic (risperidone) and an antidepressant (mirtazapine) with the objective toExpand
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By integrating knowledge gained by pharmacogenetic, neuroanatomical and pharmacological studies, a model can be constructed how serotonin (5-HT) affects the vulnerability to induce tardiveExpand
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Are immediate‐ and extended‐release drugs interchangeable?
With the continuation of the euro crisis and the economic recession, budget cuts in all sectors of society, health care not excluded, are the call of the day. However, of all the costs involved –Expand
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Polyfarmacie en irrationele combinaties van psychofarmaca bij verblijfspatiënten in het APZ: Kunstfout of onvermijdelijk?
BACKGROUND: In chronic inpatients polypharmacy is common and sometimes the combinations of psychotropics are irrational from a theoretical point of view. AIMS Registration of polypharmacy andExpand
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Circuits Regulating Pleasure and Happiness—Mechanisms of Depression
According to our model of the regulation of appetitive-searching vs. distress-avoiding behaviors, the motivation to display these essential conducts is regulated by two parallelExpand
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Gaps in health care for the somatic health of outpatients with severe mental illness.
The physical health of outpatients with severe mental illness (SMI) can be improved by changes in the health-care system. Analysis of current practice is necessary to develop these strategies. WeExpand
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Functional psychopharmacology is the way to go in pharmacotherapy for psychiatric disorders
Up to the end of the 19th century, bloodletting was a well-accepted treatment for almost everything. Until the middle of the 20th century, pyrotherapy, i.e. causing a bacterial abscess or malaria toExpand
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