A. Lohe

Publications30
h-index25
Citations2,595
Highly Influential Citations163
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Mapping simple repeated DNA sequences in heterochromatin of Drosophila melanogaster.
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Horizontal transmission, vertical inactivation, and stochastic loss of mariner-like transposable elements.
TLDR
Evidence is presented that the genome of the common ancestor of the melanogaster species subgroup of Drosophila contained an MLE related to the mellifera (honey bee) subfamily, suggesting that the predominant mode of MLE evolution is vertical inactivation and stochastic loss balanced against occasional reinvasion of lineages by horizontal transmission.
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Multiplicity of satellite DNA sequences in Drosophila melanogaster.
  • A. Lohe, D. Brutlag
  • Biology
    Proceedings of the National Academy of Sciences…
  • 1 February 1986
TLDR
The multiplicity of simple repeated sequences revealed despite the small sample size suggests that numerous repeat sequences reside in heterochromatin and that particular rules apply to the structure of the repeating sequence.
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Autoregulation of mariner transposase activity by overproduction and dominant-negative complementation.
TLDR
It is proposed that these regulatory mechanisms act at the level of the transposase protein subunits by promoting the assembly of oligomeric forms, or of mixed-subunit oligomers, that have reduced activity to mariner-like elements (MLEs).
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Modern thoughts on an ancyent marinere: function, evolution, regulation.
TLDR
Two mechanisms that may be operative in mariner regulation are identified, one mechanism is overproduction inhibition, in which excessive wild-type transposase reduces the rate of excision of a target element, and a second mechanism is dominant-negative complementation, inwhich certain mutant transpos enzyme proteins antagonize the activity of the wild- type transposable elements.
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Mutations in the mariner transposase: the D,D(35)E consensus sequence is nonfunctional.
TLDR
A simple eye-color screen is described that facilitates isolation and analysis of mutations in the mariner transposase in Drosophila melanogaster and remarkably, transpos enzyme function is obliterated when the D,D(34)D acidic, ion-binding domain is replaced with the consensus sequence D, D( 34)E found in the nematode Tc1 transPOSase and in many other transposases in the superfamily.
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What restricts the activity of mariner-like transposable elements.
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Identical satellite DNA sequences in sibling species of Drosophila.
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Fine mapping of satellite DNA sequences along the Y chromosome of Drosophila melanogaster: relationships between satellite sequences and fertility factors.
TLDR
The entirely heterochromatic Y chromosome of Drosophila melanogaster contains a series of simple sequence satellite DNAs which together account for about 80% of its length and 8 of these sequences are finely mapped by in situ hybridization on mitotic chromosome preparations.
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There are two mechanisms of achiasmate segregation in Drosophila females, one of which requires heterochromatic homology.
TLDR
It is proposed that the absence of diplotene-diakinesis during female meiosis allows heterochromatic pairings to persist until prometaphase and thus to co-orient homologous centromeres, and it is confirmed that the segregation of heterologous chromosomes is determined by size, shape, and availability.
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