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Potential antitumor agents. Part 29(1): synthesis and potential coanthracyclinic activity of imidazo[2,1-b]thiazole guanylhydrazones.
Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil.
The design, synthesis, and rapid evaluation of a new class of acetylcholinesterase (AChE) inhibitors related to donepezil are reported and a possible inhibitor binding mode in which favorable interactions are formed between the benzylpiperidinone moiety and some active-site residues is shown.
Effects of new ubiquinone-imidazo[2,1-b]thiazoles on mitochondrial complex I (NADH-ubiquinone reductase) and on mitochondrial permeability transition pore.
Synthesis and mitogenic activity of new imidazo[2,1-b]thiazoles
Synthesis and antitubercular activity of imidazo[2,1-b]thiazoles.
Novel thiazole derivatives: a patent review (2008 – 2012; Part 1)
- A. Leoni, A. Locatelli, R. Morigi, M. Rambaldi
- Chemistry, BiologyExpert opinion on therapeutic patents
- 17 January 2014
Most of the described compounds are shown to have beneficial therapeutic effects but at the same time these compounds, selective for ‘multi-signaling pathway’ targets, may also increase the side-effect potential.
Antitumor activity of substituted E-3-(3,4,5-trimethoxybenzylidene)-1,3-dihydroindol-2-ones1.
Strong COMPARE correlations among the cell line responses suggest that these compounds may be acting similarly through a combination of different mechanisms of action.
Cystic Fibrosis: A New Target for 4-Imidazo[2,1-b]thiazole-1,4-dihydropyridines
The pharmacology of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl– channel has attracted significant interest in recent years with the aim to search for rational new therapies for…
Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives.
The present investigation led to the identification of potent G-quadruplex stabilizers with high selectivity over duplex DNA and preference for one G- quadruplex topology over others.
Imidazo[2,1-b]thiazole system: a scaffold endowing dihydropyridines with selective cardiodepressant activity.
Interestingly, the novel 4-aryl-dihydropyridines are L-type calcium channel blockers with a peculiar pharmacological behavior and might be promising agents for the treatment of specific cardiovascular pathologies such as cardiac hypertrophy and ischemia.