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- Publications
- Influence
Potential antitumor agents. Part 29(1): synthesis and potential coanthracyclinic activity of imidazo[2,1-b]thiazole guanylhydrazones.
- A. Andreani, A. Leoni, +4 authors V. Garalienė
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 September 2000
This paper reports the synthesis of new imidazo[2,1-b]thiazole guanylhydrazones which were tested as potential antitumor agents. Three of these derivatives (those bearing a 3- or 4-nitrophenyl group)… Expand
Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil.
- A. Andreani, A. Cavalli, +7 authors A. Roda
- Chemistry, Medicine
- Journal of medicinal chemistry
- 2 October 2001
The design, synthesis, and rapid evaluation of a new class of acetylcholinesterase (AChE) inhibitors related to donepezil are reported. A molecular dynamics simulation of the complex between AChE and… Expand
Effects of new ubiquinone-imidazo[2,1-b]thiazoles on mitochondrial complex I (NADH-ubiquinone reductase) and on mitochondrial permeability transition pore.
- A. Andreani, M. Granaiola, +7 authors C. Bergamini
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 November 2004
In this work we describe the synthesis of a series of imidazo[2,1-b]thiazoles and 2,3-dihydroimidazo[2,1-b]thiazoles connected by means of a methylene bridge to CoQ(0). These compounds were tested as… Expand
Synthesis and mitogenic activity of new imidazo[2,1-b]thiazoles
- A. Andreani, M. Rambaldi, A. Locatelli, A. M. Isetta
- Chemistry
- 1 April 1991
Eight new imidazo[2,1-b]thiazoles were synthesized in order to evaluate their ability to stimulate the proliferation of thymic lymphocytes. The 2-chloro (5–8) proved more active than the 2,3-dimethyl… Expand
Synthesis and antitubercular activity of imidazo[2,1-b]thiazoles.
- A. Andreani, M. Granaiola, A. Leoni, A. Locatelli, R. Morigi, M. Rambaldi
- Chemistry, Medicine
- European journal of medicinal chemistry
- 1 September 2001
A number of selected imidazo[2,1-b]thiazoles entered the screening at the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) and one of these compounds,… Expand
Potential antitumor agents. 37. Synthesis and antitumor activity of guanylhydrazones from imidazo[2,1-b]thiazoles and from the new heterocyclic system thiazolo[2',3':2,3]imidazo[4,5-c]quinoline.
- A. Andreani, M. Granaiola, +7 authors G. Farruggia
- Chemistry, Medicine
- Journal of medicinal chemistry
- 18 March 2005
This paper reports synthesis and antitumor activity of new guanylhydrazones from imidazo[2,1-b]thiazoles and from the new heterocyclic system thiazolo[2',3':2,3]imidazo[4,5-c]quinoline. The compounds… Expand
Cystic Fibrosis: A New Target for 4-Imidazo[2,1-b]thiazole-1,4-dihydropyridines
- R. Budriesi, P. Ioan, +5 authors L. Galietta
- Chemistry, Medicine
- Journal of medicinal chemistry
- 28 April 2011
The pharmacology of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl– channel has attracted significant interest in recent years with the aim to search for rational new therapies for… Expand
Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives.
- J. Amato, R. Morigi, +12 authors A. Randazzo
- Chemistry, Medicine
- Journal of medicinal chemistry
- 6 June 2016
G-Quadruplex-binding compounds are currently perceived as possible anticancer therapeutics. Here, starting from a promising lead, a small series of novel hydrazone-based compounds were synthesized… Expand
4-Aminopyridine derivatives with antiamnesic activity.
- A. Andreani, A. Leoni, +4 authors G. Villetti
- Chemistry, Medicine
- European journal of medicinal chemistry
- 2000
Acetylcholine (Ach) enhancement, useful in the treatment of Alzheimer's disease (AD), may be obtained by means of ion channel modulators such as 4-aminopyridine (4-AP). 4-AP is also the central ring… Expand
Antitumor activity of new substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and study of their effect on the cell cycle.
- A. Andreani, M. Granaiola, +8 authors L. Masotti
- Chemistry, Medicine
- Journal of medicinal chemistry
- 28 July 2005
This paper reports the synthesis of a new series of 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones which were tested as potential antitumor agents at the National Cancer Institute. Two… Expand