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GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution
- M. A. Puthenveedu, C. Bachert, Sapna Puri, F. Lanni, A. Linstedt
- Medicine, Biology
- Nature Cell Biology
- 19 February 2006
The mammalian Golgi apparatus exists as stacks of cisternae that are laterally linked to form a continuous membrane ribbon, but neither the molecular requirements for, nor the purpose of, Golgi… Expand
Giantin, a novel conserved Golgi membrane protein containing a cytoplasmic domain of at least 350 kDa.
The Golgi complex consists of a series of stacked cisternae in most eukaryotes. Morphological studies indicate the existence of intercisternal cross-bridge structures that may mediate stacking, but… Expand
Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein.
- A. Linstedt, A. Mehta, J. Suhan, H. Reggio, H. Hauri
- Biology, Medicine
- Molecular biology of the cell
- 1 June 1997
It is thought that residents of the Golgi stack are localized by a retention mechanism that prevents their forward progress. Nevertheless, some early Golgi proteins acquire late Golgi modifications.… Expand
Faculty Opinions recommendation of Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.
- A. Linstedt
- 31 July 2006
Mitogen-activated protein kinase kinase 1-dependent Golgi unlinking occurs in G2 phase and promotes the G2/M cell cycle transition.
Two controversies have emerged regarding the signaling pathways that regulate Golgi disassembly at the G(2)/M cell cycle transition. The first controversy concerns the role of mitogen-activated… Expand
A primary role for Golgi positioning in directed secretion, cell polarity, and wound healing.
Peri-centrosomal positioning of the mammalian Golgi apparatus is known to involve microtubule-based motility, but its importance for cellular physiology is a major unanswered question. Here, we… Expand
GRASP55 regulates Golgi ribbon formation.
Recent work indicates that mitogen-activated protein kinase kinase (MEK)1 signaling at the G2/M cell cycle transition unlinks the contiguous mammalian Golgi apparatus and that this regulates cell… Expand
Potential role for protein kinases in regulation of bidirectional endoplasmic reticulum-to-Golgi transport revealed by protein kinase inhibitor H89.
Recent evidence suggests a regulatory connection between cell volume, endoplasmic reticulum (ER) export, and stimulated Golgi-to-ER transport. To investigate the potential role of protein kinases we… Expand
Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis
Shunning Shiga Infection with bacteria harboring Shiga toxin is responsible for more than 1 million deaths annually worldwide. Antidotes for the toxin are not available, and treatment with… Expand
Biogenesis of synaptic vesicle-like structures in a pheochromocytoma cell line PC-12
- L. Clift-O'Grady, A. Linstedt, A. W. Lowe, E. Grote, R. Kelly
- Medicine, Biology
- The Journal of cell biology
- 1 May 1990
The presence of unique proteins in synaptic vesicles of neurons suggests selective targeting during vesicle formation. Endocrine, but not other cells, also express synaptic vesicle membrane proteins… Expand