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Heparin-binding protein: an early marker of circulatory failure in sepsis.
BACKGROUND The early detection of circulatory failure in patients with sepsis is important for successful treatment. Heparin-binding protein (HBP), released from activated neutrophils, is a potentExpand
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Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock
IntroductionRapid detection of, and optimized treatment for, severe sepsis and septic shock is crucial for successful outcome. Heparin-binding protein (HBP), a potent inducer of increased vascularExpand
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Sepsis Incidence: A Population-Based Study
Background. Although sepsis is a major health problem, data on sepsis epidemiology are scarce. The aim of this study was to assess the incidence of sepsis, based on clinical findings in all adultExpand
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Small acute increases in serum creatinine are associated with decreased long-term survival in the critically ill.
RATIONALE Long-term outcomes after acute kidney injury (AKI) are poorly described. OBJECTIVES We hypothesized that one single episode of minimal (stage 1) AKI is associated with reduced long-termExpand
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Cathelicidin LL-37 in Severe Streptococcus pyogenes Soft Tissue Infections in Humans
ABSTRACT Severe soft tissue infections, such as necrotizing fasciitis and severe cellulitis, caused by group A streptococci (GAS) are rapidly progressing life-threatening infections characterized byExpand
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Antibody orientation at bacterial surfaces is related to invasive infection
Bacterial surface proteins switch the orientation of IgG binding depending on the antibody concentration of their environment.
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Roles of Heparin-Binding Protein in Bacterial Infections
Infectious diseases remain a major health problem, where sepsis and other severe infectious diseases are common causes of morbidity and mortality. The importance of early and appropriate treatment ofExpand
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Decreased plasma concentrations of apolipoprotein M in sepsis and systemic inflammatory response syndromes
IntroductionApolipoprotein M (apoM) is present in 5% of high-density lipoprotein (HDL) particles in plasma. It is a carrier of sphingosine-1-phosphate (S1P), which is important for vascular barrierExpand
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Sphingosine 1‐phosphate and its carrier apolipoprotein M in human sepsis and in Escherichia coli sepsis in baboons
Sphingosine 1‐phosphate (S1P) is an important regulator of vascular integrity and immune cell migration, carried in plasma by high‐density lipoprotein (HDL)‐associated apolipoprotein M (apoM) and byExpand
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Heparin-binding protein: A diagnostic marker of acute bacterial meningitis*
Background:The early detection of bacterial meningitis is crucial for successful outcome. Heparin-binding protein, a potent inducer of increased vascular permeability, is released from activatedExpand
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