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Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis.
- C. Daniels, M. Wilkes, +4 authors E. Leof
- The Journal of clinical investigation
- 1 November 2004
Idiopathic pulmonary fibrosis is a progressive and fatal fibrotic disease of the lungs with unclear etiology. Prior efforts to treat idiopathic pulmonary fibrosis that focused on anti-inflammatory… Expand
Pneumocystis carinii pneumonia in patients without acquired immunodeficiency syndrome: associated illness and prior corticosteroid therapy.
OBJECTIVE To determine the clinical spectrum of immunosuppressive conditions and systemic corticosteroid therapy associated with the development of Pneumocystis carinii pneumonia in a consecutive… Expand
Clinical outcomes of pulmonary Langerhans'-cell histiocytosis in adults.
- R. Vassallo, J. Ryu, D. Schroeder, P. Decker, A. Limper
- The New England journal of medicine
- 14 February 2002
BACKGROUND Pulmonary Langerhans'-cell histiocytosis is an uncommon interstitial lung disease in adults. It has an unpredictable course and may be associated with an increased susceptibility to the… Expand
Pneumocystis carinii pneumonia. Differences in lung parasite number and inflammation in patients with and without AIDS.
- A. Limper, K. Offord, T. Smith, W. Martin
- The American review of respiratory disease
- 1 November 1989
Pneumocystis carinii pneumonia has emerged as a significant cause of morbidity and mortality in immunocompromised patients with and without AIDS. To determine differences in P. carinii pneumonia in… Expand
Current insights into the biology and pathogenesis of Pneumocystis pneumonia
The fungal infection Pneumocystis pneumonia is the most prevalent opportunistic infection in patients with AIDS. Although the analysis of this opportunistic fungal pathogen has been hindered by the… Expand
Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.
- T. Broekelmann, A. Limper, T. Colby, J. A. Mcdonald
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 August 1991
Idiopathic pulmonary fibrosis is an inexorably fatal disorder characterized by connective tissue deposition within the terminal air spaces resulting in loss of lung function and eventual respiratory… Expand
An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients.
- A. Limper, K. Knox, +10 authors D. Stevens
- American journal of respiratory and critical care…
With increasing numbers of immune-compromised patients with malignancy, hematologic disease, and HIV, as well as those receiving immunosupressive drug regimens for the management of organ… Expand
Pulmonary Langerhans'-cell histiocytosis.
- R. Vassallo, J. Ryu, T. Colby, T. Hartman, A. Limper
- The New England journal of medicine
- 1 September 2004
: Pulmonary Langerhans' cell histiocytosis (PLCH) is an uncommon but important cause of interstitial lung disease, and it occurs predominantly in adult cigarette smokers. PLCH belongs to the spectrum… Expand
Stretch induces cytokine release by alveolar epithelial cells in vitro.
- N. Vlahakis, M. Schroeder, A. Limper, R. Hubmayr
- Medicine, Biology
- American journal of physiology. Lung cellular and…
- 1 July 1999
Mechanical ventilation can injure the lung, causing edema and alveolar inflammation. Interleukin-8 (IL-8) plays an important role in this inflammatory response. We postulated that cyclic cell stretch… Expand
N Engl J Med 2004;350:2487-98. Copyright © 2004 Massachusetts Medical Society. neumocystis pneumonia remains the most prevalent opportun istic infection in patients infected with the human… Expand