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Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis.
Idiopathic pulmonary fibrosis is a progressive and fatal fibrotic disease of the lungs with unclear etiology. Prior efforts to treat idiopathic pulmonary fibrosis that focused on anti-inflammatoryExpand
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Pneumocystis carinii pneumonia in patients without acquired immunodeficiency syndrome: associated illness and prior corticosteroid therapy.
OBJECTIVE To determine the clinical spectrum of immunosuppressive conditions and systemic corticosteroid therapy associated with the development of Pneumocystis carinii pneumonia in a consecutiveExpand
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Clinical outcomes of pulmonary Langerhans'-cell histiocytosis in adults.
BACKGROUND Pulmonary Langerhans'-cell histiocytosis is an uncommon interstitial lung disease in adults. It has an unpredictable course and may be associated with an increased susceptibility to theExpand
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Pneumocystis carinii pneumonia. Differences in lung parasite number and inflammation in patients with and without AIDS.
Pneumocystis carinii pneumonia has emerged as a significant cause of morbidity and mortality in immunocompromised patients with and without AIDS. To determine differences in P. carinii pneumonia inExpand
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Current insights into the biology and pathogenesis of Pneumocystis pneumonia
The fungal infection Pneumocystis pneumonia is the most prevalent opportunistic infection in patients with AIDS. Although the analysis of this opportunistic fungal pathogen has been hindered by theExpand
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Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.
Idiopathic pulmonary fibrosis is an inexorably fatal disorder characterized by connective tissue deposition within the terminal air spaces resulting in loss of lung function and eventual respiratoryExpand
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An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients.
With increasing numbers of immune-compromised patients with malignancy, hematologic disease, and HIV, as well as those receiving immunosupressive drug regimens for the management of organExpand
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Pulmonary Langerhans'-cell histiocytosis.
: Pulmonary Langerhans' cell histiocytosis (PLCH) is an uncommon but important cause of interstitial lung disease, and it occurs predominantly in adult cigarette smokers. PLCH belongs to the spectrumExpand
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Stretch induces cytokine release by alveolar epithelial cells in vitro.
Mechanical ventilation can injure the lung, causing edema and alveolar inflammation. Interleukin-8 (IL-8) plays an important role in this inflammatory response. We postulated that cyclic cell stretchExpand
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Pneumocystis pneumonia.
N Engl J Med 2004;350:2487-98. Copyright © 2004 Massachusetts Medical Society. neumocystis pneumonia remains the most prevalent opportun istic infection in patients infected with the humanExpand
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