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Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
2-Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that, forExpand
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Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
The medicinal properties of marijuana have been recognized for centuries, but clinical and societal acceptance of this drug of abuse as a potential therapeutic agent remains fiercely debated. AnExpand
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Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation
A new tissue-specific pathway for the synthesis of proinflammatory prostaglandins is described. Phospholipase A2(PLA2) enzymes are considered the primary source of arachidonic acid for cyclooxygenaseExpand
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Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo
Δ9-Tetrahydrocannabinol (THC), the psychoactive component of marijuana, and other direct cannabinoid receptor (CB1) agonists produce a number of neurobehavioral effects in mammals that range from theExpand
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Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
Prolonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to pharmacological tolerance and receptor desensitization in the nervous system. We found that a similar form ofExpand
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Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented Combination of Potency and Selectivity
Fatty acid amide hydrolase (FAAH) is the primary catabolic regulator of several bioactive lipid amides in vivo, including the endogenous cannabinoid anandamide and the sleep-inducing substanceExpand
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Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia
&NA; Although the N‐arachidonoyl ethanolamine (anandamide) binds to cannabinoid receptors and has been implicated in the suppression of pain, its rapid catabolism in vivo by fatty acid amideExpand
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Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats
The purpose of the present study was to investigate the disruptive effects of cannabinoids on working memory as assessed in the eight-arm radial-maze. Systemic administration of Δ9-THC, WIN-55,212-2,Expand
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Evaluation of CB1 receptor knockout mice in the Morris water maze.
  • S. Varvel, A. Lichtman
  • Psychology, Medicine
  • The Journal of pharmacology and experimental…
  • 1 June 2002
The endocannabinoid system has been proposed to modulate a variety of physiological processes, including those that underlie cognition. The present study tested whether this system is tonicallyExpand
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Blockade of Endocannabinoid-Degrading Enzymes Attenuates Neuropathic Pain
Direct-acting cannabinoid receptor agonists are well known to reduce hyperalgesic responses and allodynia after nerve injury, although their psychoactive side effects have damped enthusiasm for theirExpand
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