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Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy.
Preliminary studies in 11 patients suggest that extending the photoperiod with bright artificial light has an antidepressant effect and sleep recordings in nine depressed patients confirmed the presence of hypersomnia and showed increased sleep latency and reduced slow-wave (delta) sleep. Expand
Measuring melatonin in humans.
- S. Benloucif, H. Burgess, +5 authors V. Revell
- Journal of clinical sleep medicine : JCSM…
- 15 February 2008
Consensus-based guidelines are presented for collecting and analyzing melatonin for studies that are conducted in the natural living environment, the clinical setting, and in-patient research facilities under controlled conditions. Expand
Practice Guideline for the Treatment of Patients With Major Depressive Disorder, 2nd ed.
The human phase response curve (PRC) to melatonin is about 12 hours out of phase with the PRC to light.
The human phase response curve (PRC) to melatonin appears to be about 12h out of phase with the PRC to light, which suggests that a function for endogenous melatonin is to augment entrainment of the circadian pacemaker by the light-dark cycle. Expand
Antidepressant and circadian phase-shifting effects of light.
The antidepressant response to morning light was accompanied by an advance in the onset of nighttime melatonin production, suggesting that timing may be critical for the antidepressant effects of bright light. Expand
The circadian basis of winter depression.
- A. Lewy, Bryan J Lefler, J. Emens, V. Bauer
- Proceedings of the National Academy of Sciences…
- 9 May 2006
The findings support the phase-shift hypothesis for SAD, as well as suggest a way to assess the circadian component of other psychiatric, sleep, and chronobiologic disorders. Expand
Melatonin shifts human circadian rhythms according to a phase-response curve.
The human melatonin PRC provides critical information for using melatonin to treat circadian phase sleep and mood disorders, as well as maladaptation to shift work and transmeridional air travel. Expand
Morning vs evening light treatment of patients with winter depression.
- A. Lewy, V. Bauer, +5 authors J. M. Jackson
- Medicine, Psychology
- Archives of general psychiatry
- 1 October 1998
Morning light phase-advanced the dim-light melatonin onset and was more antidepressant than evening light, which phase-delayed it, which should help establish the importance of circadian time of light exposure in the treatment of winter depression. Expand
Light suppresses melatonin secretion in humans.
Findings establish that the human response to light is qualitatively similar to that of other mammals. Expand
The Endogenous Melatonin Profile as a Marker for Circadian Phase Position
The dim-light melatonin offset (DLMOff), even when operationally defined at thresholds less than 10 pg/ml, appears to be confounded by amplitude in this study; in such cases, it may be preferable to use the melatonin synthesis offset (SynOff) because it is not confounding by amplitude and because, theoretically, it is temporally closer to the endogenous mechanism signaling the offset of production. Expand