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JNK: a new therapeutic target for diabetes.
Jun N-terminal kinase (JNK) regulates the transcription factor AP-1, which is implicated in the controlled expression of many genes involved in the immune response. For this reason, drug discoveryExpand
Determination of suspended sediment concentrations and particle size distributions using pressure measurements.
We present an automated, in-situ technique for measuring suspended-sediment concentrations and particle-size distributions. The technique uses pressure transducers to continuously monitor the fluidExpand
Pharmacological methods in the control of inflammation
Offering a comprehensive overview of laboratory research models and practical experimental protocols used in the study of inflammation, this volume discusses the development and therapeuticExpand
Modulation of mouse ear edema by cyclooxygenase and lipoxygenase inhibitors and other pharmacologic agents
Inhibitors of arachidonic acid (AA) metabolism and other pharmacologic agents were evaluated against ear edema produced in mice by tetradecanoylphorbol acetate (TPA) or AA. Drugs were administeredExpand
Comparison of inflammatory changes in established type II collagen- and adjuvant-induced arthritis using outbred Wistar rats.
Type II collagen- and adjuvant-induced arthritis in outbred Wistar rats were compared using parameters that measured the inflammatory response, cellular and humoral immunity, blood protein changes,Expand
Interleukin 1 activates phospholipase A2 in rabbit chondrocytes: a possible signal for IL 1 action.
We examined the effects of Interleukin 1 (IL 1) on rabbit articular chondrocytes with particular emphasis on arachidonic acid metabolism in these cells. Articular chondrocytes were isolated from theExpand
Pre-plant treatment of Chrysanthemum × morifolium with growth retardants
Abstract Pre-plant dips of the root portion, shoot portion or entire rooted cutting in ancymidol [α-cyclopropyl-α-(θ-methoxypheny)-5-pyrimidinemethanol] or daminozide [butanedioic acid monoExpand
Inhibition of platelet and neutrophil phospholipase A2 by hydroxyeicosatetraenoic acids (HETES). A novel pharmacological mechanism for regulating free fatty acid release.
The present study demonstrated that acid-extracted platelet phospholipase A2 (PLA2) exhibited marked hydrolytic activity against both [1-14C]oleic acid- and [1-14C]arachidonic acid-labeledExpand
Correlation between mouse skin inflammation induced by arachidonic acid and eicosanoid synthesis
We and others have shown that arachidonic acid (AA), when applied topically to ear surfaces, causes an intense acute inflammatory reaction within minutes (as measured by ear thickness). In thisExpand