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Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide associationExpand
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Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease.
Children and adolescents with Crohn's disease (CD) present often with a more complicated disease course compared to adult patients. In addition, the potential impact of CD on growth, pubertal andExpand
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ESPGHAN Revised Porto Criteria for the Diagnosis of Inflammatory Bowel Disease in Children and Adolescents
Background: The diagnosis of pediatric-onset inflammatory bowel disease (PIBD) can be challenging in choosing the most informative diagnostic tests and correctly classifying PIBD into its differentExpand
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Pediatric modification of the Montreal classification for inflammatory bowel disease: The Paris classification
Background: Crohn's disease and ulcerative colitis are complex disorders with some shared and many unique predisposing genes. Accurate phenotype classification is essential in determining the utilityExpand
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Common variants at five new loci associated with early-onset inflammatory bowel disease
The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of aExpand
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Levels of drug and antidrug antibodies are associated with outcome of interventions after loss of response to infliximab or adalimumab.
BACKGROUND & AIMS There is controversy about whether levels of anti-tumor necrosis factor (TNF) and antidrug antibodies (ADAs) are accurate determinants of loss of response to therapy. We analyzedExpand
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Food allergy is a matter of geography after all: sesame as a major cause of severe IgE‐mediated food allergic reactions among infants and young children in Israel
Objective: To determine the prevalence, importance, and the order of frequency of IgE‐mediated food allergens among infants and young children in Israel.
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Evolving role of diet in the pathogenesis and treatment of inflammatory bowel diseases
Recent advances in basic and clinical science over the last 3 years have dramatically altered our appreciation of the role of diet in inflammatory bowel diseases (IBD). The marked increase inExpand
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Appraisal of the Pediatric Crohn's Disease Activity Index on Four Prospectively Collected Datasets: Recommended Cutoff Values and Clinimetric Properties
OBJECTIVES:The Pediatric Crohn's Disease Activity Index (PCDAI) is the outcome measure of choice in clinical trials of pediatric Crohn's disease. The aim of this study was to provide knowledge on itsExpand
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Consensus for Managing Acute Severe Ulcerative Colitis in Children: A Systematic Review and Joint Statement From ECCO, ESPGHAN, and the Porto IBD Working Group of ESPGHAN
OBJECTIVES:Acute severe ulcerative colitis (ASC) is a potentially life-threatening disease. We aimed to formulate guidelines for managing ASC in children based on systematic review of the literatureExpand
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