A. Lesniak

Publications46
h-index10
Citations325
Highly Influential Citations5
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Canine olfactory receptor gene polymorphism and its relation to odor detection performance by sniffer dogs.
The outstanding sensitivity of the canine olfactory system has been acknowledged by using sniffer dogs in military and civilian service for detection of a variety of odors. It is hypothesized that… Expand
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Biological evaluation and molecular docking studies of AA3052, a compound containing a μ-selective opioid peptide agonist DALDA and d-Phe-Phe-d-Phe-Leu-Leu-NH2, a substance P analogue.
The design of novel drugs for pain relief with improved analgesic properties and diminished side effect induction profile still remains a challenging pursuit. Tolerance is one of the most burdensome… Expand
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Biphalin preferentially recruits peripheral opioid receptors to facilitate analgesia in a mouse model of cancer pain - A comparison with morphine.
The search for new drugs for cancer pain management has been a long-standing goal in basic and clinical research. Classical opioid drugs exert their primary antinociceptive effect upon activating… Expand
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Chronic mild stress facilitates melanoma tumor growth in mouse lines selected for high and low stress-induced analgesia
Abstract Both chronic stress conditions and hyperergic reaction to environmental stress are known to enhance cancer susceptibility. We described two mouse lines that displayed high (HA) and low (LA)… Expand
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A polymorphism in exon 2 of the δ-opioid receptor affects nociception in response to specific agonists and antagonists in mice selectively bred for high and low analgesia
&NA; This study searched for polymorphic sites in the murine &mgr;‐, &dgr;‐ and &kgr;‐opioid receptors that presumably influence pain perception. We employed two mouse lines divergently bred for high… Expand
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Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.
A reported mixed opioid agonist - neurokinin 1 receptor (NK1R) antagonist 4 (Dmt-D-Arg-Aba-Gly-(3',5'-(CF3)2)NMe-benzyl) was modified to identify important features in both pharmacophores. The new… Expand
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Opioid peptides in peripheral pain control.
Opioids have a long history of therapeutic use as a remedy for various pain states ranging from mild acute nociceptive pain to unbearable chronic advanced or end-stage disease pain. Analgesia… Expand
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Identification of Dmt-D-Lys-Phe-Phe-OH as a highly antinociceptive tetrapeptide metabolite of the opioid-neurotensin hybrid peptide PK20.
BACKGROUND Recently, we presented a novel compound (PK20, Dmt-D-Lys-Phe-Phe-Lys-Lys-Pro-Phe-Tle-Leu-OH) that targets single entity opioid and neurotensin pharmacophores. This endomorphin-2-like… Expand
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Importance of N‐ and C‐terminal residues of substance P 1–7 for alleviating allodynia in mice after peripheral administration
Abstract The heptapeptide SP1–7 (1, Arg1‐Pro2‐Lys3‐Pro4‐Gln5‐Gln6‐Phe7) is the major bioactive metabolite formed after proteolytic processing of the neuropeptide substance P (SP,… Expand
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Association between the A107V substitution in the δ‐opioid receptors and ethanol drinking in mice selected for high and low analgesia
Experimental evidence suggests that endogenous opioids play an important role in the development of ethanol addiction. In this study, we employed two mouse lines divergently bred for opioid‐mediated… Expand
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