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Full-term pregnancies achieved with ICSI despite high levels of sperm chromatin damage.
There is still controversy over whether analytical techniques currently in use are able to identify the level of damage to spermatozoa and large-scale studies should be conducted in different clinical settings to determine the effects of sperm DNA damage on the outcome of ART. Expand
Lipids of the sperm plasma membrane: from polyunsaturated fatty acids considered as markers of sperm function to possible scavenger therapy.
A specific composition of phospholipids and a significant concentration of polyunsaturated fatty acids (PUFA) have been shown to be present in sperm membranes and Seminal plasma has a highly specialized scavenger system that defends the sperm membrane against lipoperoxidation. Expand
Molecular and clinical characterization of Y chromosome microdeletions in infertile men: a 10-year experience in Italy.
- A. Ferlin, B. Arredi, +5 authors C. Foresta
- Biology, Medicine
- The Journal of clinical endocrinology and…
- 1 March 2007
This extensive clinical research expands the knowledge on genotype-phenotype relationships and confirms that the identification of Yq microdeletions has significant diagnostic and prognostic value, adding useful information for genetic counseling in these patients. Expand
Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle‐aged men: a meta‐analysis
A systematic review of randomized controlled trials evaluating the effects of testosterone administration to middle‐aged and ageing men on body composition, muscle strength, bone density, markers of bone metabolism and serum lipid profile concludes that androgen treatment might be beneficial in these subjects. Expand
Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 24-month, randomized,…
TU reduced fasting glucose, waist circumference, and improved surrogate markers of atherosclerosis in hypogonadal men with MS without significant hematological and prostate adverse events. Expand
Study of apoptotic DNA fragmentation in human spermatozoa.
The results suggest that apoptosis could be the final result of various pathologies and of a deregulation of spermatogenesis control systems. Expand
Development and validation of a 6-item version of the female sexual function index (FSFI) as a diagnostic tool for female sexual dysfunction.
The abridged FSFI-6 is a novel tool that can help any doctor to disclose FSD rapidly and efficiently and is a valuable tool for screening women that are likely to suffer from FSD. Expand
Testosterone and metabolic syndrome: a meta-analysis study.
A meta-analysis of the available cross-sectional data suggests that MetS can be considered an independent association of male hypogonadism and TRT seems to improve metabolic control, as well as central obesity. Expand
Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial.
Based on a controlled study of efficacy, L-carnitine therapy was effective in increasing semen quality, especially in groups with lower baseline levels, however, these results need to be confirmed by larger clinical trials and in vitro studies. Expand
Effects of testosterone on sexual function in men: results of a meta‐analysis
A systematic review and meta‐analysis of placebo‐controlled studies published in the past 30 years to clarify whether sexual function would benefit from testosterone treatment in men with partially or severely reduced serum T levels. Expand