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Full-term pregnancies achieved with ICSI despite high levels of sperm chromatin damage.
There is still controversy over whether analytical techniques currently in use are able to identify the level of damage to spermatozoa and large-scale studies should be conducted in different clinical settings to determine the effects of sperm DNA damage on the outcome of ART.
Lipids of the sperm plasma membrane: from polyunsaturated fatty acids considered as markers of sperm function to possible scavenger therapy.
A specific composition of phospholipids and a significant concentration of polyunsaturated fatty acids (PUFA) have been shown to be present in sperm membranes and Seminal plasma has a highly specialized scavenger system that defends the sperm membrane against lipoperoxidation.
Molecular and clinical characterization of Y chromosome microdeletions in infertile men: a 10-year experience in Italy.
- A. Ferlin, B. Arredi, C. Foresta
- Biology, MedicineThe Journal of clinical endocrinology and…
- 1 March 2007
This extensive clinical research expands the knowledge on genotype-phenotype relationships and confirms that the identification of Yq microdeletions has significant diagnostic and prognostic value, adding useful information for genetic counseling in these patients.
Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle‐aged men: a meta‐analysis
A systematic review of randomized controlled trials evaluating the effects of testosterone administration to middle‐aged and ageing men on body composition, muscle strength, bone density, markers of bone metabolism and serum lipid profile concludes that androgen treatment might be beneficial in these subjects.
Study of apoptotic DNA fragmentation in human spermatozoa.
The results suggest that apoptosis could be the final result of various pathologies and of a deregulation of spermatogenesis control systems.
Testosterone and metabolic syndrome: a meta-analysis study.
A meta-analysis of the available cross-sectional data suggests that MetS can be considered an independent association of male hypogonadism and TRT seems to improve metabolic control, as well as central obesity.
Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 24-month, randomized,…
TU reduced fasting glucose, waist circumference, and improved surrogate markers of atherosclerosis in hypogonadal men with MS without significant hematological and prostate adverse events.
Development and validation of a 6-item version of the female sexual function index (FSFI) as a diagnostic tool for female sexual dysfunction.
The abridged FSFI-6 is a novel tool that can help any doctor to disclose FSD rapidly and efficiently and is a valuable tool for screening women that are likely to suffer from FSD.
Study of SARS-CoV-2 in semen and urine samples of a volunteer with positive naso-pharyngeal swab
- D. Paoli, F. Pallotti, F. Lombardo
- Medicine, BiologyJournal of Endocrinological Investigation
- 23 April 2020
It may be possible that either the viral clearance kinetics in these matrices matches the progressive clinical recovery of the patient or that the virus was never present in these fluids at the time of the laboratory diagnosis.