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An intracellular anion channel critical for pigmentation
TLDR
Direct patch-clamp of skin and eye melanosomes is used to identify a novel chloride-selective anion conductance mediated by OCA2 and required for melanin production, suggesting that the chloride channel might regulate melanin synthesis by modulating melanosome pH.
Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes
TLDR
A quantitative proteomic approach that enabled unbiased identification of major histocompatibility complex class II (MHCII)–associated peptide epitopes and biochemical features of antigenicity and a deep neural network model for genome-scale predictions of immunodominant MHCII-restricted epitopes are developed.
Increased autophagic sequestration in adaptor protein-3 deficient dendritic cells limits inflammasome activity and impairs antibacterial immunity
TLDR
A novel link between phagocytosis, inflammasome activity and autophagy in DCs is identified, potentially explaining impaired antibacterial immunity in AP-3-deficient patients.
SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation
TLDR
The data suggest that SLC45A2 maintains melanosome neutralization that is initially orchestrated by transient OCA2 activity to support melanization at late stages of melanosomes maturation, and that a common allelic variant imparts reduced activity due to protein instability.
SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation
TLDR
The data indicate that SLC45A2 maintains melanosome neutralization – initially orchestrated by transient OCA2 activity – to support melanization at late stages of melanosomes maturation, and that a common variant imparts reduced activity due to protein instability.
QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis
TLDR
QRICH1 is identified as a transcriptional regulator controlling adaptation to ER stress at the level of protein translation and secretion and the role of the QRICH1 program in inflammatory diseases of the colon and liver is demonstrated.
A missense variant in SLC39A8 confers risk for Crohn’s disease by disrupting manganese homeostasis and intestinal barrier integrity
TLDR
A murine model for the Slc39a8 A391T allele is generated and it is demonstrated that these mice exhibit Mn deficiency in the colon associated with impaired intestinal barrier function and epithelial glycocalyx disruption, leading to indolent inflammation that can prime further inflammation driven by epithelial injury.
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