• Publications
  • Influence
Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results
TLDR
The combined clinimetric results of this study support the validity of the MDS‐UPDRS for rating PD. Expand
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
TLDR
The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported, and these observations call into question current concepts of Parkinson's Disease as a single distinct morbid entity. Expand
Clinical diagnostic criteria for dementia associated with Parkinson's disease
TLDR
Clinical diagnostic criteria for probable and possible PD‐D are proposed, characterized by impairment in attention, memory, executive and visuo‐spatial functions, behavioral symptoms such as affective changes, hallucinations, and apathy are frequent. Expand
Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Process, format, and clinimetric testing plan
TLDR
The MDS‐UPDRS retains the UPDRS structure of four parts with a total summed score, but the parts have been modified to provide a section that integrates nonmotor elements of PD: I, Nonmotor Experiences of Daily Living; II, Motor Exper experiences of daily Living; III, Motor Examination; and IV, Motor Complications. Expand
Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease
TLDR
The cloning of a novel gene that contains missense mutations segregating with PARK8-linked PD in five families from England and Spain is described and this protein is named dardarin, derived from the Basque word dardara, meaning tremor, because of the tremor observed in PD. Expand
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
TLDR
Mutations in LRRK2 are a clinically relevant cause of PD that merit testing in patients with hereditary PD and in subgroups of patients with PD, but this knowledge should be applied with caution in the diagnosis and counselling of patients. Expand
Rivastigmine for dementia associated with Parkinson's disease.
TLDR
Rivastigmine was associated with moderate improvements in dementia associated with Parkinson's disease but also with higher rates of nausea, vomiting, and tremor; however, the differences between these two groups were moderate and similar to those reported in trials of rivastIGmine for Alzheimer's disease. Expand
Diagnostic procedures for Parkinson's disease dementia: Recommendations from the movement disorder society task force
  • B. Dubois, D. Burn, +18 authors M. Emre
  • Psychology, Medicine
  • Movement disorders : official journal of the…
  • 15 December 2007
TLDR
The main focus of this article is to operationalize the diagnosis of PD‐D and to propose pratical guidelines based on a two level process depending upon the clinical scenario and the expertise of the evaluator involved in the assessment. Expand
Punding in Parkinson's disease: Its relation to the dopamine dysregulation syndrome
TLDR
It is believed that punding is an underreported, socially disabling phenomenon that is commonly associated with the syndrome of dopamine dysregulation and is phenomenologically distinct from both obsessive‐compulsive disorder and mania. Expand
Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease.
TLDR
It is demonstrated that GBA mutations are found in British subjects at a higher frequency than any other known Parkinson's disease gene and suggested that to date, this is the most common genetic factor identified for the disease. Expand
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