• Publications
  • Influence
Diagnosis and management of dementia with Lewy bodies
TLDR
The authors propose a new scheme for the pathologic assessment of LBs and Lewy neurites (LN) using alpha-synuclein immunohistochemistry and semiquantitative grading of lesion density, with the pattern of regional involvement being more important than total LB count. Expand
Second consensus statement on the diagnosis of multiple system atrophy
TLDR
New criteria for diagnosis of multiple system atrophy have simplified the previous criteria, have incorporated current knowledge, and are expected to enhance future assessments of the disease. Expand
The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.
  • W. Gibb, A. Lees
  • Medicine
  • Journal of neurology, neurosurgery, and…
  • 1 June 1988
TLDR
Associated pathological findings suggest that cases of incidental Lewy body disease are presymptomatic cases of Parkinson's disease, and confirm the importance of age (time) in the evolution of the disease. Expand
Ageing and Parkinson's disease: substantia nigra regional selectivity.
TLDR
It is suggested that age-related attrition of pigmented nigral cells is not an important factor in the pathogenesis of Parkinson's disease and the regional selectivity of PD is relatively specific. Expand
Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia.
TLDR
An increase in total iron content appears to be a response to neurodegeneration in affected basal ganglia regions in a number of movement disorders, suggesting an alteration of iron handling in the substantia nigra in PD. Expand
Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease
TLDR
The results may indicate that an increased level of lipid peroxidation continues to occur in the parkinsonian nigra up to the time of death, perhaps because of continued exposure to excess free radicals derived from some endogenous or exogenous neurotoxic species. Expand
Cognitive deficits in the early stages of Parkinson's disease.
  • A. Lees, E. Smith
  • Psychology, Medicine
  • Brain : a journal of neurology
  • 1 June 1983
TLDR
Patients with Parkinson's disease had significantly greater difficulty in shifting conceptual sets and produced more perseverative errors on both the modified Wisconsin Card Sorting Test and Benton's Word Fluency Test, suggesting subtle cognitive difficulties might underlie the mental inflexibility and rigidity of Parkinson's Disease. Expand
Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra
TLDR
Analysis of products of oxidation and deamination of all four DNA bases in control and PD brains showed that levels of 8‐hydroxyguanine (8‐OHG) tended to be elevated and levels of 2,6‐diamino‐4‐Hydroxy‐5‐formamidopyrimidine (FAPy guanine) tendedto be decreased in PD, but the most striking difference was a rise in 8‐ OHG in PD substantia nigra. Expand
Impaired activation of the supplementary motor area in Parkinson's disease is reversed when akinesia is treated with apomorphine
TLDR
It is concluded that the concomitant improvement of supplementary motor area activation and motor function in apomorphine‐treated patients with PD provides further evidence for the role of this structure in generating motor programs. Expand
PINK1 protein in normal human brain and Parkinson's disease.
TLDR
In vivo morphological and biochemical evidence is provided for the first time to support a mitochondrial localization of PINK1 and underpin the significance of mitochondrial dysfunction in the pathogenesis of nigral cell degeneration in Parkinson's disease. Expand
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