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CDC25 phosphatases as potential human oncogenes.
Cyclin-dependent kinases (CDKs) are activated by CDC25 phosphatases, which remove inhibitory phosphate from tyrosine and threonine residues. In human cells, CDC25 proteins are encoded by a multigeneExpand
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Stress and mortality in a small marsupial (Antechinus stuartii, Macleay).
An investigation was made into the role of increased adrenocortical activity in the causation of the total postmating mortality of male Antechinus stuartii—a small shrew-like marsupial. A progressiveExpand
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Inhibition of lipopolysaccharide‐inducible nitric oxide synthase, TNF‐α and COX‐2 expression by sauchinone effects on I‐κBα phosphorylation, C/EBP and AP‐1 activation
Sauchinone, a lignan isolated from Saururus chinensis (Saururaceae), is a diastereomeric lignan with cytoprotective and antioxidant activities in cultured hepatocytes. The effects of sauchinone onExpand
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Endocrine changes in dasyurid marsupials with differing mortality patterns.
A comparison was made between the breeding-related endocrine changes in two species of dasyurid marsupial (Antechinus swainsonii and A. flavipes), which exhibit a catastrophic male mortality after aExpand
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Effects of acute renal failure on the pharmacokinetics of chlorzoxazone in rats.
  • Y. Moon, A. Lee, +6 authors M. Lee
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 June 2003
The purpose of this study is to report the changes of CYP2E1, CYP1A2, CYP2B1/2, CYP2C11, CYP3A23, and CYP3A2 expression and pharmacokinetics and tissue distribution of chlorzoxazone (CZX) andExpand
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Pharmacokinetics of theophylline in diabetes mellitus rats: induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation.
  • Y. Kim, A. Lee, +5 authors M. Lee
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 1 September 2005
Pharmacokinetic parameters of theophylline and one of its metabolites, 1,3-dimethyluric acid (1,3-DMU), were compared after intravenous and oral administration of aminophylline, 5mg/kg asExpand
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Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation.
1. Sauchinone, a lignan isolated from Saururus chinensis (Saururaceae), is a diastereomeric lignan with cytoprotective and antioxidant activities in cultured hepatocytes. The effects of sauchinone onExpand
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Pharmacokinetics of 5-fluorouracil in rats with diabetes mellitus induced by streptozotocin.
The pharmacokinetic parameters of 5-fluorouracil were compared after intravenous administration at a dose of 30 mg/kg to control Sprague-Dawley rats and to rats with diabetes mellitus induced byExpand
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Australian Desert Mice: Independence of Exogenous Water
Certain Australian desert mice can survive and may gain weight on a diet of dry seed without drinking water. Urine concentrations for two of the three species studied are the highest recorded forExpand
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Effects of cysteine on the pharmacokinetics of intravenous torasemide in rats with protein-calorie malnutrition.
  • S. Bae, D. Y. Lee, +6 authors M. Lee
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 1 September 2004
Effects of cysteine on the pharmacokinetics of torasemide were investigated after intravenous administration at a dose of 2 mg/kg to control rats and rats with PCM and PCMC. Torasemide was reportedExpand
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