• Publications
  • Influence
Lipid-protein interactions in biological membranes: a structural perspective.
  • A. Lee
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 2 May 2003
Lipid molecules bound to membrane proteins are resolved in some high-resolution structures of membrane proteins. An analysis of these structures provides a framework within which to analyse theExpand
Reconstitution of a calcium pump using defined membrane components.
TLDR
A fully functional Ca(2+) pump containing essentially a single protein and exogenous lipid has been achieved using a single step centrifugation procedure. Expand
Curcumin, a Molecule That Inhibits the Ca2+-ATPase of Sarcoplasmic Reticulum but Increases the Rate of Accumulation of Ca2+ *
TLDR
Simulations suggest that the effect of curcumin is to reduce the rate of slippage on the ATPase, a process in which a Ca2+-bound, phosphorylated intermediate releases its bound Ca2+, on the cytoplasmic rather than on the lumenal side of the membrane. Expand
Lipid phase transitions and phase diagrams. I. Lipid phase transitions.
  • A. Lee
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 9 August 1977
How lipids interact with an intrinsic membrane protein: the case of the calcium pump.
  • A. Lee
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 10 November 1998
Ca2+-ATPase can be purified from the skeletal muscle of sarcoplasmic reticulum and reconstituted into phospholipid bilayers of defined composition. This allows a detailed study of the interactionsExpand
Ca2+ -ATPase structure in the E1 and E2 conformations: mechanism, helix-helix and helix-lipid interactions.
  • A. Lee
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 11 October 2002
TLDR
The irregular packing of the TM alpha-helices in the Ca(2+)-ATPase, combined with the diffuse structure of the ATPase on the lumenal side of the membrane, is suggested to lead to a relative low activation energy for changing the packing ofThe experimentally determined TMalpha- helices do not agree well with those predicted theoretically. Expand
What the structure of a calcium pump tells us about its mechanism.
TLDR
The report of the crystal structure of the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum in its Ca( 2+)-bound form provides an opportunity to interpret much kinetic and mutagenic data on the ATPase in structural terms. Expand
Membrane lipids: It’s only a phase
  • A. Lee
  • Biology, Medicine
  • Current Biology
  • 15 May 2000
All biological membranes contain lipids that prefer to adopt a non-bilayer phase. Recent results suggest that, in the thylakoid membrane, membrane proteins force all the lipids to adopt a bilayerExpand
Hydrophobic mismatch and the incorporation of peptides into lipid bilayers: a possible mechanism for retention in the Golgi.
TLDR
Hydrophobic mismatch could explain retention of proteins with short trans-membrane alpha-helical domains in the Golgi, the effect following largely from the low concentration of cholesterol in the golgi membrane compared to that in the plasma membrane. Expand
Lipid phase transitions and phase diagrams. II. Mictures involving lipids.
  • A. Lee
  • Medicine
  • Biochimica et biophysica acta
  • 14 November 1977
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