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- Publications
- Influence
Droplet microfluidics.
- S. Teh, R. Lin, Lung-Hsin Hung, A. Lee
- Medicine
- Lab on a chip
- 2008
Droplet-based microfluidic systems have been shown to be compatible with many chemical and biological reagents and capable of performing a variety of "digital fluidic" operations that can be rendered… Expand
Human neural stem cell growth and differentiation in a gradient-generating microfluidic device.
- B. Chung, L. Flanagan, +4 authors N. L. Jeon
- Biology, Medicine
- Lab on a chip
- 23 March 2005
This paper describes a gradient-generating microfluidic platform for optimizing proliferation and differentiation of neural stem cells (NSCs) in culture. Microfluidic technology has great potential… Expand
Unique Dielectric Properties Distinguish Stem Cells and Their Differentiated Progeny
- L. Flanagan, Jente Lu, +4 authors E. Monuki
- Biology, Medicine
- Stem cells
- 1 March 2008
The relatively new field of stem cell biology is hampered by a lack of sufficient means to accurately determine the phenotype of cells. Cell‐type‐specific markers, such as cell surface proteins used… Expand
Alternating droplet generation and controlled dynamic droplet fusion in microfluidic device for CdS nanoparticle synthesis.
- Lung-Hsin Hung, K. Choi, Wei-Yu Tseng, Yung-Chieh Tan, K. Shea, A. Lee
- Materials Science, Medicine
- Lab on a chip
- 31 January 2006
A multifunctional and high-efficiency microfluidic device for droplet generation and fusion is presented. Through unique design of the micro-channels, the device is able to alternately generate… Expand
On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging.
- K. Hettiarachchi, E. Talu, M. Longo, P. Dayton, A. Lee
- Materials Science, Medicine
- Lab on a chip
- 27 March 2007
This paper presents a new manufacturing method to generate monodisperse microbubble contrast agents with polydispersity index (sigma) values of <2% through microfluidic flow-focusing. Micron-sized… Expand
Design of microfluidic channel geometries for the control of droplet volume, chemical concentration, and sorting.
- Yung-Chieh Tan, J. S. Fisher, A. Lee, V. Cristini, A. Lee
- Chemistry, Medicine
- Lab on a chip
- 19 July 2004
Passive microfluidic channel geometries for control of droplet fission, fusion and sorting are designed, fabricated, and tested. In droplet fission, the inlet width of the bifurcating junction is… Expand
In vitro perfused human capillary networks.
- M. Moya, Y. Hsu, A. Lee, C. Hughes, S. George
- Biology, Medicine
- Tissue engineering. Part C, Methods
- 21 February 2013
Replicating in vitro the complex in vivo tissue microenvironment has the potential to transform our approach to medicine and also our understanding of biology. In order to accurately model the 3D… Expand
1-Million droplet array with wide-field fluorescence imaging for digital PCR.
- A. C. Hatch, J. S. Fisher, +5 authors A. Lee
- Chemistry, Medicine
- Lab on a chip
- 21 October 2011
Digital droplet reactors are useful as chemical and biological containers to discretize reagents into picolitre or nanolitre volumes for analysis of single cells, organisms, or molecules. However,… Expand
PLGA micro/nanosphere synthesis by droplet microfluidic solvent evaporation and extraction approaches.
- Lung-Hsin Hung, S. Teh, J. Jester, A. Lee
- Materials Science, Medicine
- Lab on a chip
- 29 June 2010
In this paper, we present two approaches for the synthesis of poly(lactide-co-glycolide) (PLGA) micro/nanospheres using non-toxic organic solvents in droplet-based microfluidic platforms. Solvent… Expand
Engineering microscale cellular niches for three-dimensional multicellular co-cultures.
- Carlos Huang, Jente Lu, +5 authors N. L. Jeon
- Chemistry, Medicine
- Lab on a chip
- 21 June 2009
Modeling the in vivo microenvironment typically involves placing cells in a three-dimensional (3D) extracellular matrix (ECM) in physiologically relevant context with respect to other cells. The… Expand