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Antiplasmodial, anti-chikungunya virus and antioxidant activities of 64 endemic plants from the Mascarene Islands.
Seasonal Effect on the Chemical Composition, Insecticidal Properties and Other Biological Activities of Zanthoxylum leprieurii Guill. & Perr. Essential Oils
TLDR
Essential oils exhibited high insecticidal activities against Sitophilus granarius, as well as antioxidant, anti-inflammatory and moderate anti-plasmodial properties, and statistical analyses of essential oil compositions showed that the variability mainly comes from the organs.
The Inhibition of NLRP3 Inflammasome and IL-6 Production by Hibiscus noldeae Baker f. Derived Constituents Provides a Link to Its Anti-Inflammatory Therapeutic Potentials
TLDR
This work provides the very first scientific based evidence for Hibiscus noldeae anti-inflammatory effects and widespread use by traditional healers in Rwanda for a variety of ailments.
In vitro antiplasmodial and cytotoxic activities of sesquiterpene lactones from Vernonia fimbrillifera Less. (Asteraceae)
TLDR
Cytotoxicity of the compounds against a human cancer cell line (HeLa) and a mouse lung epithelial cell line was assessed to determine selectivity and compound 3 displayed promising selective antiplasmodial activity.
Phytochemical Profile and Biological Activity Evaluation of Zanthoxylum heterophyllum Leaves against Malaria
TLDR
The moderate antiplasmodial activity of hydroxy- γ -isosanshool was demonstrated for the first time and is the first report of the presence of a sanshool derivative in Z. heterophyllum.
Flavonoid composition, cellular antioxidant activity and (myelo)peroxidase inhibition of a Bryonia alba L. (Cucurbitaceae) leaves extract
The aim of the present study consisted in the isolation of flavonoids from the leaves of Bryonia alba L. and evaluation of their antioxidant activity and inhibition on peroxidase‐catalysed reactions.
Antimalarial Activities of Alkyl Cyclohexenone Derivatives Isolated from the Leaves of Poupartia borbonica.
TLDR
In vitro cytotoxicity against WI38 human fibroblasts and the human cervical cancer cell line HeLa (WST-1 assay) showed that these compounds were also cytotoxic, but no hemolytic activity was observed for the extract and pure compounds.
In vivo Antimalarial and Antitrypanosomal Activity of Strychnogucine B, a Bisindole Alkaloid from Strychnos icaja.
TLDR
Strychnogucine B is a bisindole alkaloid previously isolated from Strychnos icaja that possesses promising in vitro antiplasmodial properties and shows moderate in vitro antitrypanosomal activity but no in vivo activity in an acute Trypanosoma brucei model.
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