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A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding.
The inclusion of the 270-nucleotide human fibronectin ED1 exon in HeLa cells requires the presence of a centrally located 81-nucleotide exon sequence. We have conducted a series of in vitroExpand
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High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene.
We have investigated the role of the p53 gene in oncogenesis in vivo by generating transgenic mice carrying murine p53 genomic fragments isolated from a mouse Friend erythroleukemia cell line orExpand
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Insertional inactivation of the p53 gene during friend leukemia: a new strategy for identifying tumor suppressor genes.
Rearrangements within the p53 gene are observed in a high proportion of independent erythroleukemic cell lines derived from the spleens of mice infected with Friend leukemia virus. The majority ofExpand
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Characterization of allelic V kappa-1 region genes in inbred strains of mice.
Germ line genes encoding mouse Ig kappa-chains belonging to the V kappa-1 group have been isolated from BALB/c, NZB, and CE, three inbred strains of differing kappa haplotype. The V kappa-1A and VExpand
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Structure and genetic control of Vk-1 light chains
Resume L'analyse de la sequence en acides amines des regions V L d'un ensemble de chaines legeres K permet de definir, au sein du sous-groupe V κ 1, trois sous-familles tres etroitement apparenteesExpand
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Species-specific regulation of alternative splicing in the C-terminal region of the p53 tumor suppressor gene.
Alternative splicing occurs in the C-terminal region of the p53 tumor suppressor gene between two alternative 3' splice sites in intron 10. This alternative splicing event has been detected in murineExpand
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p53 transgenic mice: accelerated erythroleukemia induction by Friend virus.
Mutations in the p53 tumor-suppressor gene have been implicated in the pathogenesis of a significant proportion of human cancers and in a dominantly inherited familial cancer syndrome (Li-FraumeniExpand
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HighIncidence ofLung,Bone,andLymphoid TumorsinTransgenic MiceOverexpressing MutantAlleles ofthep53Oncogene
We haveinvestigated therole ofthep53geneinoncogenesis invivobygenerating transgenic micecarrying murine p53genomic fragments isolated froma mouse Friend erythroleukemia cell line orBALB/cmouse liverExpand