Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?
- A. Laurenza, E. Sutkowski, K. Seamon
- BiologyTIPS - Trends in Pharmacological Sciences
- 1 November 1989
Efficacy and safety of adjunctive perampanel for the treatment of refractory partial seizures: A pooled analysis of three phase III studies
- B. Steinhoff, E. Ben-Menachem, A. Laurenza
- PsychologyEpilepsia
- 1 August 2013
Three phase III studies evaluated perampanel, an α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor antagonist, as adjunctive therapy for refractory partial seizures, and report post hoc analyses of pooled study data by randomized dose.
Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy
- J. French, G. Krauss, F. Bibbiani
- MedicineNeurology
- 15 September 2015
This study provides Class I evidence that adjunctive perampanel reduces PGTC seizure frequency, compared with placebo, in patients with drug-resistant PGTC seizures in IGE.
Adjunctive perampanel for refractory partial-onset seizures
- J. French, G. Krauss, M. Rogawski
- Medicine, PsychologyNeurology
- 7 August 2012
This trial demonstrated that once-daily, adjunctive perampanel at doses of 8 or 12 mg improved seizure control in patients with uncontrolled partial-onset seizures.
Evaluation of adjunctive perampanel in patients with refractory partial‐onset seizures: Results of randomized global phase III study 305
- J. French, G. Krauss, A. Laurenza
- MedicineEpilepsia
- 1 January 2013
Purpose: To assess the efficacy and safety of once‐daily doses of perampanel 8 and 12 mg when added to 1–3 concomitantly administered, approved antiepileptic drugs (AEDs) in patients with…
A Randomized, Double-Blind, Placebo-Controlled Study of Sumatriptan Nasal Spray in the Treatment of Acute Migraine in Adolescents
- P. Winner, A. Rothner, M. Peykamian
- MedicinePediatrics
- 1 November 2000
Sumatriptan NS is effective and well-tolerated for the treatment of acute migraine in adolescents, with the 20-mg dose providing the best overall efficacy and tolerability profiles.
Naratriptan is Effective and Well Tolerated in the Acute Treatment of Migraine. Results of a Double‐Blind, Placebo‐Controlled, Parallel‐Group Study
- A. Klassen, A. Elkind, M. Asgharnejad, C. Webster, A. Laurenza
- Medicine, PsychologyHeadache
- 1 November 1997
Evaluation of the efficacy and tolerability of naratriptan, a novel 5‐HT1 agonist, in the acute treatment of migraine and its application in patients with migraine is evaluated.
Randomized phase III study 306
- G. Krauss, J. Serratosa, A. Laurenza
- Medicine, PsychologyNeurology
- 1 May 2012
This trial demonstrated that adjunctive perampanel effectively reduced seizure frequency and possessed a favorable tolerability profile in patients ≥12 years with partial-onset seizures (with or without secondary generalization), with a minimum effective dose of 4 mg/day.
Stimulation of adenylate cyclase by water-soluble analogues of forskolin.
- A. Laurenza, Y. Khandelwal, N. J. de Souza, R. H. Rupp, H. Metzger, K. Seamon
- Biology, ChemistryMolecular Pharmacology
- 1 July 1987
Water-soluble derivatives of forskolin may be useful for increasing cyclic AMP in broken cell preparations or in intact cell preparations where the presence of organic solvents, which are necessary to solubilize forskol, are detrimental.
Cognitive effects of adjunctive perampanel for partial‐onset seizures: A randomized trial
- K. Meador, Hai-chen Yang, J. E. Pina-garza, A. Laurenza, Dinesh Kumar, K. Wesnes
- PsychologyEpilepsia
- 1 January 2016
The objective of this study was to assess cognitive effects of adjunctive perampanel in adolescents and to establish a baseline level of trust in the use of the drug.
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