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Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe
In Guadeloupe, epidemiological data have linked atypical parkinsonism with fruit and herbal teas from plants of the Annonaceae family, particularly Annona muricata, and these plants contain a class of powerful, lipophilic complex I inhibitors, the annonaceous acetogenins, which support the hypothesis that some forms of parkinsonist might be induced by environmental toxins. Expand
The mitochondrial complex i inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism
This study demonstrates that annonacin promotes dopaminergic neuronal death by impairment of energy production and underlines the need to address its possible role in the etiology of some atypical forms of Parkinsonism in Guadeloupe. Expand
Antiparasitic activities of medicinal plants used in Ivory Coast.
During an ethnopharmacological survey of antiparasitic medicinal plants used in Ivory Coast, 17 plants were identified and collected and antimalarial, leishmanicidal, trypanocidal, antihelminthiasis and antiscabies activities were determined. Expand
Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe
Atypical parkinsonism in Guadeloupe has been associated with the consumption of fruit and infusions or decoctions prepared from leaves of Annona muricata L. (Annonaceae), which contains annonaceousExpand
Cytotoxic and antiparasitic activity from Annona senegalensis seeds.
Several extracts of Annona senegalensis (Annonaceae) seeds were tested for antiparasitic activity against Leishmania major, Leishmania donovani, Trypanosoma brucei brucei, and for cytotoxic activityExpand
Coronin from roots of Annona muricata, a putative intermediate in acetogenin biosynthesis (1).
Coronin is probably an intermediate in the biosynthetic pathway of bis-tetrahydrofuran acetogenins, and is proposed as a biogenetic precursor of neoannonin-B. Expand
Squamocin and benzyl benzoate, acaricidal components of Uvaria pauci-ovulata bark extracts.
Annonaceae have been commonly described in traditional medicine as remedies against head lice and for their insecticidal properties and squamocin was shown to potentiate the activity of benzyl benzoate using the fractional effective concentration (FEC) method. Expand
Recent advances in the fight against leishmaniasis with natural products.
Natural compounds with antileishmanial activity are coumarins, chalcones, lactones, tetralones and saponins, some of them are known antiprotozoal natural products. Expand
Antiparasitic activity of Annona muricata and Annona cherimolia seeds.
The acetogenins isolated from these extracts are found to be responsible for the important activity on infective larvae of Molinema desetae. Expand
Cohibins C and D, two important metabolites in the biogenesis of acetogenins from Annona muricata and Annona nutans.
Two new annonaceous acetogenins, cohibins C (1a) and D (1b), have been isolated by extensive chromatography of a hexane extract of Annona muricata seeds and a cyclohexane extract of Annona nutansExpand