• Publications
  • Influence
Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications.
The prevalence of atrial fibrillation (AF) is related to age. Anticoagulation is highly effective in preventing stroke in patients with AF, but the risk of hemorrhage may be increased in olderExpand
  • 1,978
  • 54
An assessment of clinically useful measures of the consequences of treatment.
WITH neither the time nor the resources available to prevent, detect, or treat every disorder in every patient, which preventive, diagnostic, or therapeutic interventions should take priority? When aExpand
  • 1,247
  • 45
SPIRIT 2013 statement: defining standard protocol items for clinical trials.
The protocol of a clinical trial serves as the foundation for study planning, conduct, reporting, and appraisal. However, trial protocols and existing protocol guidelines vary greatly in content andExpand
  • 1,596
  • 45
A study of the quality of life and cost-utility of renal transplantation.
The objective of this study was to assess the cost-utility of renal transplantation compared with dialysis. To accomplish this, a prospective cohort of pre-transplant patients were followed for up toExpand
  • 923
  • 39
How attractive does a new technology have to be to warrant adoption and utilization? Tentative guidelines for using clinical and economic evaluations.
Because economic evaluations of health care services are being published with increasing frequency it is important to (a) evaluate them rigorously and (b) compare the net benefit of the applicationExpand
  • 1,390
  • 31
Clinical prediction rules. A review and suggested modifications of methodological standards.
BACKGROUND Clinical prediction rules are decision-making tools for clinicians, containing variables from the history, physical examination, or simple diagnostic tests. OBJECTIVE To review theExpand
  • 1,046
  • 31
The practice guidelines development cycle: a conceptual tool for practice guidelines development and implementation.
PURPOSE To develop a conceptual tool for the systematic development of cancer treatment practice guidelines. MATERIALS AND METHODS The guidelines development tool, the Practice GuidelinesExpand
  • 451
  • 24
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials
Summary Background The vascular and gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors (coxibs) and traditional non-steroidalExpand
  • 972
  • 21
Assessing the quality of randomized trials: reliability of the Jadad scale.
An instrument was developed and validated by Jadad, et al. to assess the quality of clinical trials using studies from the pain literature. Our study determined the reliability of the Jadad scale andExpand
  • 417
  • 18
Canadian Atrial Fibrillation Anticoagulation (CAFA) Study.
The Canadian Atrial Fibrillation Anticoagulation Study was a randomized double-blind placebo-controlled trial to assess the potential of warfarin to reduce systemic thromboembolism and its inherentExpand
  • 896
  • 17